Implications of Exercise-Induced Pulmonary Arterial Hypertension
Purpose: To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. Methods: A total of 37 symptomati...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Lippincott Williams & Wilkins
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/41052 |
| _version_ | 1848756037885100032 |
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| author | Fowler, R. Maiorana, Andrew Jenkins, Susan Gain, Kevin O'Driscoll, G. Gabbay, E. |
| author_facet | Fowler, R. Maiorana, Andrew Jenkins, Susan Gain, Kevin O'Driscoll, G. Gabbay, E. |
| author_sort | Fowler, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. Methods: A total of 37 symptomatic patients at risk of PAH and 20 healthy controls underwent a cardiopulmonary exercise test and were assessed for quality of life (QOL). Patients had a pulmonary artery catheter in situ during the exercise test. Results: Seventeen subjects had exercise-induced PAH (EIPAH), which we defined as mPAP ≤ 25 mm Hg at rest, and mPAP > 30 mm Hg and pulmonary artery wedge pressure <20 mm Hg on exercise. These subjects had reduced peak exercise cardiac output (72% ± 19% predicted). Further, compared with matched controls, subjects with EIPAH had reduced peak oxygen consumption (1.2 ± 0.4 vs 1.7 ± 0.5 L•min−1, P < 0.05), an elevated ventilatory equivalent for carbon dioxide (41.0 ± 7.3 vs 31.0 ± 2.9, P < 0.05) and reduced end-tidal carbon dioxide tension (32.6 ± 3.6 vs 39.4 ± 2.7 mm Hg, P < 0.05) at the anaerobic threshold. These exercise abnormalities were associated with impaired QOL (P < 0.05). Conclusions: Elevated pulmonary artery pressure on exercise can be associated with hemodynamic and ventilatory abnormalities typical of PAH, along with impaired exercise capacity and reduced QOL. |
| first_indexed | 2025-11-14T09:05:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-41052 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:05:50Z |
| publishDate | 2011 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-410522017-09-13T16:09:10Z Implications of Exercise-Induced Pulmonary Arterial Hypertension Fowler, R. Maiorana, Andrew Jenkins, Susan Gain, Kevin O'Driscoll, G. Gabbay, E. Purpose: To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. Methods: A total of 37 symptomatic patients at risk of PAH and 20 healthy controls underwent a cardiopulmonary exercise test and were assessed for quality of life (QOL). Patients had a pulmonary artery catheter in situ during the exercise test. Results: Seventeen subjects had exercise-induced PAH (EIPAH), which we defined as mPAP ≤ 25 mm Hg at rest, and mPAP > 30 mm Hg and pulmonary artery wedge pressure <20 mm Hg on exercise. These subjects had reduced peak exercise cardiac output (72% ± 19% predicted). Further, compared with matched controls, subjects with EIPAH had reduced peak oxygen consumption (1.2 ± 0.4 vs 1.7 ± 0.5 L•min−1, P < 0.05), an elevated ventilatory equivalent for carbon dioxide (41.0 ± 7.3 vs 31.0 ± 2.9, P < 0.05) and reduced end-tidal carbon dioxide tension (32.6 ± 3.6 vs 39.4 ± 2.7 mm Hg, P < 0.05) at the anaerobic threshold. These exercise abnormalities were associated with impaired QOL (P < 0.05). Conclusions: Elevated pulmonary artery pressure on exercise can be associated with hemodynamic and ventilatory abnormalities typical of PAH, along with impaired exercise capacity and reduced QOL. 2011 Journal Article http://hdl.handle.net/20.500.11937/41052 10.1249/MSS.0b013e318204cdac Lippincott Williams & Wilkins unknown |
| spellingShingle | Fowler, R. Maiorana, Andrew Jenkins, Susan Gain, Kevin O'Driscoll, G. Gabbay, E. Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title | Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title_full | Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title_fullStr | Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title_full_unstemmed | Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title_short | Implications of Exercise-Induced Pulmonary Arterial Hypertension |
| title_sort | implications of exercise-induced pulmonary arterial hypertension |
| url | http://hdl.handle.net/20.500.11937/41052 |