Ascochlorin enhances the sensitivity of doxorubicin leading to the reversal of epithelial-to-mesenchymal transition in hepatocellular carcinoma

QR Code

Ascochlorin enhances the sensitivity of doxorubicin leading to the reversal of epithelial-to-mesenchymal transition in hepatocellular carcinoma

Increasing evidence has indicated that epithelial-to-mesenchymal transition (EMT) at the advanced stage of liver cancer not only has the ability to self-renew and progress cancer, but also enables greater resistance to conventional chemo- and radiotherapies. Here, we report that ascochlorin (ASC), a...

Full description

Bibliographic Details
Main Authors:	Dai, X., Ahn, K., Wang, L., Kim, C., Deivasigamni, A., Arfuso, Frank, Um, J., Kumar, Alan Prem, Chang, Y., Kumar, D., Kundu, G., Magae, J., Goh, B., Hui, K., Sethi, G.
Format:	Journal Article
Published:	American Association for Cancer Research 2016
Online Access:	http://hdl.handle.net/20.500.11937/4098

Similar Items

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
by: Dai, X., et al.
Published: (2015)

Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy
by: Min-Wen, J., et al.
Published: (2017)

Dysregulation of Nrf2 in hepatocellular carcinoma: Role in cancer progression and chemoresistance
by: Raghunath, A., et al.
Published: (2018)

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
by: Dai, X., et al.
Published: (2017)

Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
by: Siveen, K., et al.
Published: (2014)

The role of resveratrol in cancer therapy
by: Ko, J., et al.
Published: (2017)

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
by: Sethi, G., et al.
Published: (2014)

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
by: Rajendran, P., et al.
Published: (2012)

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
by: Subramaniam, A., et al.
Published: (2013)

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model
by: Kim, C., et al.
Published: (2018)

Manganese Superoxide Dismutase Expression Regulates the Switch between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma
by: Loo, S., et al.
Published: (2016)

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma
by: Swamy, S., et al.
Published: (2016)

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen, K., et al.
Published: (2014)

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins
by: Subramaniam, Aruljothi, et al.
Published: (2013)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators
by: Bhuvanalakshmi, G., et al.
Published: (2017)

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
by: Subramaniam, A., et al.
Published: (2012)

Pharmacological utilization of bergamottin, derived from grapefruits, in cancer prevention and therapy
by: Ko, J., et al.
Published: (2018)

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
by: Rajendran, P., et al.
Published: (2011)

Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma
by: Manu, K., et al.
Published: (2013)

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
by: Rajendran, P., et al.
Published: (2011)

Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties
by: Bhuvanalakshmi, G., et al.
Published: (2015)

Novel 1,3,4-oxadiazole induces anticancer activity by targeting NF-ÎºB in hepatocellular carcinoma cells
by: Mohan, C., et al.
Published: (2018)

Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use
by: Baxter-Holland, M., et al.
Published: (2018)

Triterpenoids and sesquiterpenoids for prostate cancer therapy
by: Shanmugam, M., et al.
Published: (2016)

Role of RNF20 in cancer development and progression – a comprehensive review
by: Sethi, G., et al.
Published: (2018)

Development of a novel azaspirane that targets the Janus Kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo
by: Mohan, C., et al.
Published: (2014)

Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
by: Razak, Eliza, et al.
Published: (2016)

Hepatocellular Carcinoma
by: Tirnitz-Parker, Janine
Published: (2019)

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition
by: Warrier, Sudha, et al.
Published: (2014)

Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition
by: Hodge, S., et al.
Published: (2009)

Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo
by: Rajendran, P., et al.
Published: (2012)

NF-κB in cancer therapy
by: Li, F., et al.
Published: (2015)

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy
by: Dai, X., et al.
Published: (2015)

Selenium and hepatocellular carcinoma
by: Nasar Alwahaibi,, et al.
Published: (2008)

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2018)

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2017)

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells
by: Schwab, R., et al.
Published: (2017)

The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
by: Arora, L., et al.
Published: (2018)

N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-kB signaling pathway
by: Mohan, C., et al.
Published: (2018)

Mouse Models of Hepatocellular Carcinoma
by: Carlessi, Rodrigo, et al.
Published: (2019)