The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping
We have found a previously unreported precerebellar nucleus located among the emerging fibers of the motor root of the trigeminal nerve in the mouse, which we have called the interfascicular trigeminal nucleus (IF5). This nucleus had previously been named the tensor tympani part of the motor trigemi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Wiley
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/40904 |
| _version_ | 1848755995939962880 |
|---|---|
| author | Fu, Y. Tvrdik, P. Makki, N. Machold, R. Paxinos, G. Watson, Charles |
| author_facet | Fu, Y. Tvrdik, P. Makki, N. Machold, R. Paxinos, G. Watson, Charles |
| author_sort | Fu, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | We have found a previously unreported precerebellar nucleus located among the emerging fibers of the motor root of the trigeminal nerve in the mouse, which we have called the interfascicular trigeminal nucleus (IF5). This nucleus had previously been named the tensor tympani part of the motor trigeminal nucleus (5TT) in rodent brain atlases, because it was thought to be a subset of small motor neurons of the motor trigeminal nucleus innervating the tensor tympani muscle. However, following injection of retrograde tracer in the cerebellum, the labeled neurons in IF5 were found to be choline acetyltransferase (ChAT) negative, indicating that they are not motor neurons. The cells of IF5 are strongly labeled in mice from Wnt1Cre and Atoh1 CreER lineage fate mapping, in common with the major precerebellar nuclei that arise from the rhombic lip and that issue mossy fibers. Analysis of sections from mouse Hoxa3, Hoxb1, and Egr2 Cre labeled lineages shows that the neurons of IF5 arise from rhombomeres caudal to rhombomere 4, most likely from rhombomeres 6–8. We conclude that IF5 is a significant precerebellar nucleus in the mouse that shares developmental gene expression characteristics with mossy fiber precerebellar nuclei that arise from the caudal rhombic lip. |
| first_indexed | 2025-11-14T09:05:10Z |
| format | Journal Article |
| id | curtin-20.500.11937-40904 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:05:10Z |
| publishDate | 2012 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-409042018-03-29T09:07:32Z The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping Fu, Y. Tvrdik, P. Makki, N. Machold, R. Paxinos, G. Watson, Charles motor trigeminal nucleus rhombic lip pontine nuclei principal sensory trigeminal nucleus tensor tympani We have found a previously unreported precerebellar nucleus located among the emerging fibers of the motor root of the trigeminal nerve in the mouse, which we have called the interfascicular trigeminal nucleus (IF5). This nucleus had previously been named the tensor tympani part of the motor trigeminal nucleus (5TT) in rodent brain atlases, because it was thought to be a subset of small motor neurons of the motor trigeminal nucleus innervating the tensor tympani muscle. However, following injection of retrograde tracer in the cerebellum, the labeled neurons in IF5 were found to be choline acetyltransferase (ChAT) negative, indicating that they are not motor neurons. The cells of IF5 are strongly labeled in mice from Wnt1Cre and Atoh1 CreER lineage fate mapping, in common with the major precerebellar nuclei that arise from the rhombic lip and that issue mossy fibers. Analysis of sections from mouse Hoxa3, Hoxb1, and Egr2 Cre labeled lineages shows that the neurons of IF5 arise from rhombomeres caudal to rhombomere 4, most likely from rhombomeres 6–8. We conclude that IF5 is a significant precerebellar nucleus in the mouse that shares developmental gene expression characteristics with mossy fiber precerebellar nuclei that arise from the caudal rhombic lip. 2012 Journal Article http://hdl.handle.net/20.500.11937/40904 10.1002/cne.23200 Wiley restricted |
| spellingShingle | motor trigeminal nucleus rhombic lip pontine nuclei principal sensory trigeminal nucleus tensor tympani Fu, Y. Tvrdik, P. Makki, N. Machold, R. Paxinos, G. Watson, Charles The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title | The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title_full | The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title_fullStr | The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title_full_unstemmed | The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title_short | The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| title_sort | interfascicular trigeminal nucleus: a precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping |
| topic | motor trigeminal nucleus rhombic lip pontine nuclei principal sensory trigeminal nucleus tensor tympani |
| url | http://hdl.handle.net/20.500.11937/40904 |