The effect on melanoma risk of genes previously associated with telomere length
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Isr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/40881 |
| _version_ | 1848755989722955776 |
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| author | Iles, M. Bishop, D. Taylor, J. Hayward, N. Brossard, M. Cust, A. Dunning, A. Lee, J. Moses, Eric Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarra, G. Brown, K. Debniak, T. Elder, D. Friedman, E. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Harland, M. Helsing, P. Hoçevar, M. Hoiom, V. Ingvar, C. Kanetsky, P. Landi, M. Lang, J. Lathrop, G. Lubinski, J. Mackie, R. Martin, N. Molven, A. Montgomery, G. Novakovi, S. Olsson, H. Puig, S. Puig-Butille, J. Radford-Smith, G. Randerson-Moor, J. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Macgregor, S. Pooley, K. Ward, S. Mann, G. Amos, C. Pharoah, P. Demenais, F. Law, M. Bishop, J. Barrett, J. |
| author_facet | Iles, M. Bishop, D. Taylor, J. Hayward, N. Brossard, M. Cust, A. Dunning, A. Lee, J. Moses, Eric Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarra, G. Brown, K. Debniak, T. Elder, D. Friedman, E. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Harland, M. Helsing, P. Hoçevar, M. Hoiom, V. Ingvar, C. Kanetsky, P. Landi, M. Lang, J. Lathrop, G. Lubinski, J. Mackie, R. Martin, N. Molven, A. Montgomery, G. Novakovi, S. Olsson, H. Puig, S. Puig-Butille, J. Radford-Smith, G. Randerson-Moor, J. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Macgregor, S. Pooley, K. Ward, S. Mann, G. Amos, C. Pharoah, P. Demenais, F. Law, M. Bishop, J. Barrett, J. |
| author_sort | Iles, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk. |
| first_indexed | 2025-11-14T09:05:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-40881 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:05:04Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-408812019-05-01T03:34:26Z The effect on melanoma risk of genes previously associated with telomere length Iles, M. Bishop, D. Taylor, J. Hayward, N. Brossard, M. Cust, A. Dunning, A. Lee, J. Moses, Eric Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarra, G. Brown, K. Debniak, T. Elder, D. Friedman, E. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Harland, M. Helsing, P. Hoçevar, M. Hoiom, V. Ingvar, C. Kanetsky, P. Landi, M. Lang, J. Lathrop, G. Lubinski, J. Mackie, R. Martin, N. Molven, A. Montgomery, G. Novakovi, S. Olsson, H. Puig, S. Puig-Butille, J. Radford-Smith, G. Randerson-Moor, J. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Macgregor, S. Pooley, K. Ward, S. Mann, G. Amos, C. Pharoah, P. Demenais, F. Law, M. Bishop, J. Barrett, J. Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk. 2014 Journal Article http://hdl.handle.net/20.500.11937/40881 10.1093/jnci/dju267 http://creativecommons.org/licenses/by/3.0/ unknown |
| spellingShingle | Iles, M. Bishop, D. Taylor, J. Hayward, N. Brossard, M. Cust, A. Dunning, A. Lee, J. Moses, Eric Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarra, G. Brown, K. Debniak, T. Elder, D. Friedman, E. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Harland, M. Helsing, P. Hoçevar, M. Hoiom, V. Ingvar, C. Kanetsky, P. Landi, M. Lang, J. Lathrop, G. Lubinski, J. Mackie, R. Martin, N. Molven, A. Montgomery, G. Novakovi, S. Olsson, H. Puig, S. Puig-Butille, J. Radford-Smith, G. Randerson-Moor, J. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Macgregor, S. Pooley, K. Ward, S. Mann, G. Amos, C. Pharoah, P. Demenais, F. Law, M. Bishop, J. Barrett, J. The effect on melanoma risk of genes previously associated with telomere length |
| title | The effect on melanoma risk of genes previously associated with telomere length |
| title_full | The effect on melanoma risk of genes previously associated with telomere length |
| title_fullStr | The effect on melanoma risk of genes previously associated with telomere length |
| title_full_unstemmed | The effect on melanoma risk of genes previously associated with telomere length |
| title_short | The effect on melanoma risk of genes previously associated with telomere length |
| title_sort | effect on melanoma risk of genes previously associated with telomere length |
| url | http://hdl.handle.net/20.500.11937/40881 |