Efficient drug delivery using SiO2-layered double hydroxide nanocomposites
MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug deliver...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Academic Press
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/40818 |
| _version_ | 1848755972954128384 |
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| author | Li, L. Gu, Z. Gu, W. Liu, Jian Xu, Z. |
| author_facet | Li, L. Gu, Z. Gu, W. Liu, Jian Xu, Z. |
| author_sort | Li, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10–15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth. |
| first_indexed | 2025-11-14T09:04:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-40818 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:04:48Z |
| publishDate | 2016 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-408182017-09-13T14:02:52Z Efficient drug delivery using SiO2-layered double hydroxide nanocomposites Li, L. Gu, Z. Gu, W. Liu, Jian Xu, Z. MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10–15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth. 2016 Journal Article http://hdl.handle.net/20.500.11937/40818 10.1016/j.jcis.2016.02.042 Academic Press restricted |
| spellingShingle | Li, L. Gu, Z. Gu, W. Liu, Jian Xu, Z. Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title_full | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title_fullStr | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title_full_unstemmed | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title_short | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites |
| title_sort | efficient drug delivery using sio2-layered double hydroxide nanocomposites |
| url | http://hdl.handle.net/20.500.11937/40818 |