Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency onantiretroviral therapy are associated with T-cell activation and senescence

Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency onantiretroviral therapy are associated with T-cell activation and senescence

Objective: To examine the relationship of defects in interleukin (IL)-7-induced naive CD4+ T-cell homeostasis with residual immune activation and CD4+ T-cell senescence in HIV patients receiving antiretroviral therapy (ART) who exhibit persistent CD4+ T-cell deficiency. Design: IL-7 induced prolife...

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Bibliographic Details
Main Authors: Tanaskovic, S., Fernandez, S., Price, Patricia, French, M.
Format: Journal Article
Published: Lippincott Williams and Wilkins 2014
Subjects:
Signal transducer and activator of transcription 5 phosphorylation
Senescence
Interleukin-7
HIV
Immune activation
CD127
Online Access:http://hdl.handle.net/20.500.11937/40746

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