Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery
Differing from general melt polymer blending, a sophisticated electrospinning technique to produce continuous polylactic acid (PLA) and poly(ε-caprolactone) (PCL) hybrid fibers was employed to develop favorable fibrous networks of polymer blends for the application of drug delivery. Three typical co...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Book Chapter |
| Published: |
Wiley VCH
2015
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/40682 |
| _version_ | 1848755936223559680 |
|---|---|
| author | Haroosh, Hazim Jasim Mohammed Dong, Yu |
| author2 | Stoyko Fakirov |
| author_facet | Stoyko Fakirov Haroosh, Hazim Jasim Mohammed Dong, Yu |
| author_sort | Haroosh, Hazim Jasim Mohammed |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Differing from general melt polymer blending, a sophisticated electrospinning technique to produce continuous polylactic acid (PLA) and poly(ε-caprolactone) (PCL) hybrid fibers was employed to develop favorable fibrous networks of polymer blends for the application of drug delivery. Three typical cosolvents, consisting of chloroform (CHCl3)/acetone (C3H6O), chloroform (CHCl3)/methanol (MeOH), and dichloromethane (DCM)/N,N-dimethylformamide (DMF), were employed to form high- and low-molecular-weight PCL solutions at 9 and 15 wt%/v with 8 wt%/v PLA, respectively. Such systematic development focused on investigating the effects of polymeric solution variables, such as solution viscosity, polymer molecular weight, solution concentration, polymer blend ratio, and solvent types, on fiber diameters, morphological structures, and thermal properties associated with the degree of crystallinity and rates of drug release. The results show that the formation of bead-free hybrid fibers is ascribed to the increased molecular weight and concentration of polymer solutions. The molecular weight of PCL and cosolvent type have greatly influenced the degree of crystallinity and thermal parameters such as glass transition temperature (Tg), melting temperature (Tm), crystallization temperature (Tc) of PCL components in polymer blends. Finally, the biodegradation rate is accelerated when blending PLA/PCL with a low PCL concentration of 9 wt%/v while the slower release rate of tetracycline hydrochloride drug (TCH) is revealed in the blends with a high PCL concentration of 15 wt%/v. |
| first_indexed | 2025-11-14T09:04:13Z |
| format | Book Chapter |
| id | curtin-20.500.11937-40682 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:04:13Z |
| publishDate | 2015 |
| publisher | Wiley VCH |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-406822017-09-13T13:41:44Z Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery Haroosh, Hazim Jasim Mohammed Dong, Yu Stoyko Fakirov fibres material characterisation electrospinning poly(e-caprolactone) (PCL) drug delivery polylactic acid (PLA) Differing from general melt polymer blending, a sophisticated electrospinning technique to produce continuous polylactic acid (PLA) and poly(ε-caprolactone) (PCL) hybrid fibers was employed to develop favorable fibrous networks of polymer blends for the application of drug delivery. Three typical cosolvents, consisting of chloroform (CHCl3)/acetone (C3H6O), chloroform (CHCl3)/methanol (MeOH), and dichloromethane (DCM)/N,N-dimethylformamide (DMF), were employed to form high- and low-molecular-weight PCL solutions at 9 and 15 wt%/v with 8 wt%/v PLA, respectively. Such systematic development focused on investigating the effects of polymeric solution variables, such as solution viscosity, polymer molecular weight, solution concentration, polymer blend ratio, and solvent types, on fiber diameters, morphological structures, and thermal properties associated with the degree of crystallinity and rates of drug release. The results show that the formation of bead-free hybrid fibers is ascribed to the increased molecular weight and concentration of polymer solutions. The molecular weight of PCL and cosolvent type have greatly influenced the degree of crystallinity and thermal parameters such as glass transition temperature (Tg), melting temperature (Tm), crystallization temperature (Tc) of PCL components in polymer blends. Finally, the biodegradation rate is accelerated when blending PLA/PCL with a low PCL concentration of 9 wt%/v while the slower release rate of tetracycline hydrochloride drug (TCH) is revealed in the blends with a high PCL concentration of 15 wt%/v. 2015 Book Chapter http://hdl.handle.net/20.500.11937/40682 10.1002/9783527656950.ch8 Wiley VCH restricted |
| spellingShingle | fibres material characterisation electrospinning poly(e-caprolactone) (PCL) drug delivery polylactic acid (PLA) Haroosh, Hazim Jasim Mohammed Dong, Yu Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title | Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title_full | Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title_fullStr | Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title_full_unstemmed | Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title_short | Systematic development of electrospun PLA/PCL fibre hybrid mats: Preparation, material characterisation and application in drug delivery |
| title_sort | systematic development of electrospun pla/pcl fibre hybrid mats: preparation, material characterisation and application in drug delivery |
| topic | fibres material characterisation electrospinning poly(e-caprolactone) (PCL) drug delivery polylactic acid (PLA) |
| url | http://hdl.handle.net/20.500.11937/40682 |