Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein
Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for med...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/40510 |
| _version_ | 1848755890747867136 |
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| author | Lau, E. Johnson, Stuart Stanley, R. Mikkelsen, D. Fang, Zhongxiang Halley, P. Steadman, K. |
| author_facet | Lau, E. Johnson, Stuart Stanley, R. Mikkelsen, D. Fang, Zhongxiang Halley, P. Steadman, K. |
| author_sort | Lau, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for medication such as prednisolone, which is used in the management of inflammatory bowel disease. Therefore, prednisolone was loaded into microparticles of kafirin from the different sources using phase separation. Differences were observed in the protein content, in vitro protein digestibility, and protein electrophoretic profile of the various sources of sorghum grains, kafirin extracts, and kafirin microparticles. For all of the formulations, the majority of the loaded prednisolone was not released in in vitro conditions simulating the upper gastrointestinal tract, indicating that most of the encapsulated drug could reach the target area of the lower gastrointestinal tract. This suggests that these kafirin microparticles may have potential as a colon-targeted nutraceutical and drug delivery system. |
| first_indexed | 2025-11-14T09:03:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-40510 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:03:30Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-405102017-09-13T14:08:48Z Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein Lau, E. Johnson, Stuart Stanley, R. Mikkelsen, D. Fang, Zhongxiang Halley, P. Steadman, K. Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for medication such as prednisolone, which is used in the management of inflammatory bowel disease. Therefore, prednisolone was loaded into microparticles of kafirin from the different sources using phase separation. Differences were observed in the protein content, in vitro protein digestibility, and protein electrophoretic profile of the various sources of sorghum grains, kafirin extracts, and kafirin microparticles. For all of the formulations, the majority of the loaded prednisolone was not released in in vitro conditions simulating the upper gastrointestinal tract, indicating that most of the encapsulated drug could reach the target area of the lower gastrointestinal tract. This suggests that these kafirin microparticles may have potential as a colon-targeted nutraceutical and drug delivery system. 2015 Journal Article http://hdl.handle.net/20.500.11937/40510 10.1155/2015/343647 Hindawi Publishing Corporation fulltext |
| spellingShingle | Lau, E. Johnson, Stuart Stanley, R. Mikkelsen, D. Fang, Zhongxiang Halley, P. Steadman, K. Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title | Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title_full | Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title_fullStr | Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title_full_unstemmed | Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title_short | Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein |
| title_sort | preparation and in vitro release of drug-loaded microparticlesfor oral delivery using wholegrain sorghum kafirin protein |
| url | http://hdl.handle.net/20.500.11937/40510 |