Mechanistic roles for calcium and vitamin D in the regulation of body weight
Low intakes of calcium and inadequate vitamin D status often cluster with higher prevalence rates of obesity. Consequently, there has been much interest in the mechanisms by which calcium and vitamin D could regulate body weight and adiposity. This review has focused on randomized controlled trials...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Wiley-Blackwell Publishing Ltd.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/40302 |
| _version_ | 1848755832788877312 |
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| author | Soares, Mario Muhardi, Leilani Kurpad, A. Chan She Ping-Delfos, Wendy Piers, L. |
| author_facet | Soares, Mario Muhardi, Leilani Kurpad, A. Chan She Ping-Delfos, Wendy Piers, L. |
| author_sort | Soares, Mario |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Low intakes of calcium and inadequate vitamin D status often cluster with higher prevalence rates of obesity. Consequently, there has been much interest in the mechanisms by which calcium and vitamin D could regulate body weight and adiposity. This review has focused on randomized controlled trials (RCTs) that have manipulated these nutrients and studied pathways of energy balance. Overall, there is consistent evidence that calcium and vitamin D increase whole body fat oxidation after single and multiple meals, and that calcium promotes a modest energy loss through increased faecal fat excretion. The evidence is equivocal for a greater diet-induced thermogenesis, increased lipolysis, suppression of key lipogenic enzymes, decreased hunger ratings or reduced energy/macronutrient intake. Emerging evidence suggests a potential improvement in insulin sensitivity following vitamin D that would impinge on food intake and substrate oxidation. However, the very few RCTs on supplemental vitamin D and energy balance have not explored postprandial avenues of the hormone's actions. Future efforts in this area need to define the threshold intake of these nutrients that would maximize metabolic and gastrointestinal outcomes. Such studies would provide a platform for endorsing the non-skeletal role of calcium and vitamin D in human pathophysiology. |
| first_indexed | 2025-11-14T09:02:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-40302 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:02:34Z |
| publishDate | 2012 |
| publisher | Wiley-Blackwell Publishing Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-403022017-09-13T16:08:34Z Mechanistic roles for calcium and vitamin D in the regulation of body weight Soares, Mario Muhardi, Leilani Kurpad, A. Chan She Ping-Delfos, Wendy Piers, L. Low intakes of calcium and inadequate vitamin D status often cluster with higher prevalence rates of obesity. Consequently, there has been much interest in the mechanisms by which calcium and vitamin D could regulate body weight and adiposity. This review has focused on randomized controlled trials (RCTs) that have manipulated these nutrients and studied pathways of energy balance. Overall, there is consistent evidence that calcium and vitamin D increase whole body fat oxidation after single and multiple meals, and that calcium promotes a modest energy loss through increased faecal fat excretion. The evidence is equivocal for a greater diet-induced thermogenesis, increased lipolysis, suppression of key lipogenic enzymes, decreased hunger ratings or reduced energy/macronutrient intake. Emerging evidence suggests a potential improvement in insulin sensitivity following vitamin D that would impinge on food intake and substrate oxidation. However, the very few RCTs on supplemental vitamin D and energy balance have not explored postprandial avenues of the hormone's actions. Future efforts in this area need to define the threshold intake of these nutrients that would maximize metabolic and gastrointestinal outcomes. Such studies would provide a platform for endorsing the non-skeletal role of calcium and vitamin D in human pathophysiology. 2012 Journal Article http://hdl.handle.net/20.500.11937/40302 10.1111/j.1467-789X.2012.00986.x Wiley-Blackwell Publishing Ltd. restricted |
| spellingShingle | Soares, Mario Muhardi, Leilani Kurpad, A. Chan She Ping-Delfos, Wendy Piers, L. Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title | Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title_full | Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title_fullStr | Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title_full_unstemmed | Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title_short | Mechanistic roles for calcium and vitamin D in the regulation of body weight |
| title_sort | mechanistic roles for calcium and vitamin d in the regulation of body weight |
| url | http://hdl.handle.net/20.500.11937/40302 |