Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges
A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and int...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Science
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/40057 |
| _version_ | 1848755762785943552 |
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| author | Paterson, S. Shadforth, A. Shaw, J. Brown, David Chirila, T. Baker, M. |
| author_facet | Paterson, S. Shadforth, A. Shaw, J. Brown, David Chirila, T. Baker, M. |
| author_sort | Paterson, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 µm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalized with RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets. |
| first_indexed | 2025-11-14T09:01:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-40057 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:01:28Z |
| publishDate | 2013 |
| publisher | Elsevier Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-400572019-02-19T05:35:18Z Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges Paterson, S. Shadforth, A. Shaw, J. Brown, David Chirila, T. Baker, M. Sponges PHEMA Peptide ligands Cell invasion A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 µm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalized with RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets. 2013 Journal Article http://hdl.handle.net/20.500.11937/40057 10.1016/j.msec.2013.08.011 Elsevier Science fulltext |
| spellingShingle | Sponges PHEMA Peptide ligands Cell invasion Paterson, S. Shadforth, A. Shaw, J. Brown, David Chirila, T. Baker, M. Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title | Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title_full | Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title_fullStr | Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title_full_unstemmed | Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title_short | Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges |
| title_sort | improving the cellular invasion into phema sponges by incorporation of the rgd peptide ligand: the use of copolymerization as a means to functionalize phema sponges |
| topic | Sponges PHEMA Peptide ligands Cell invasion |
| url | http://hdl.handle.net/20.500.11937/40057 |