Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis
The objectives of this study were to explore the existence of subgroups in a cohort with chronic low back pain (n = 294) based on the results of multimodal sensory testing and profile subgroups on demographic, psychological, lifestyle, and general health factors. Bedside (2-point discrimination, bru...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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ELSEVIER SCIENCE BV
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/40054 |
| _version_ | 1848755761894653952 |
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| author | Rabey, Martin Slater, Helen O'Sullivan, Peter Beales, Darren Smith, Anne |
| author_facet | Rabey, Martin Slater, Helen O'Sullivan, Peter Beales, Darren Smith, Anne |
| author_sort | Rabey, Martin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The objectives of this study were to explore the existence of subgroups in a cohort with chronic low back pain (n = 294) based on the results of multimodal sensory testing and profile subgroups on demographic, psychological, lifestyle, and general health factors. Bedside (2-point discrimination, brush, vibration and pinprick perception, temporal summation on repeated monofilament stimulation) and laboratory (mechanical detection threshold, pressure, heat and cold pain thresholds, conditioned pain modulation) sensory testing were examined at wrist and lumbar sites. Data were entered into principal component analysis, and 5 component scores were entered into latent class analysis. Three clusters, with different sensory characteristics, were derived. Cluster 1 (31.9%) was characterised by average to high temperature and pressure pain sensitivity. Cluster 2 (52.0%) was characterised by average to high pressure pain sensitivity. Cluster 3 (16.0%) was characterised by low temperature and pressure pain sensitivity. Temporal summation occurred significantly more frequently in cluster 1. Subgroups were profiled on pain intensity, disability, depression, anxiety, stress, life events, fear avoidance, catastrophizing, perception of the low back region, comorbidities, body mass index, multiple pain sites, sleep, and activity levels. Clusters 1 and 2 had a significantly greater proportion of female participants and higher depression and sleep disturbance scores than cluster 3. The proportion of participants undertaking <300 minutes per week of moderate activity was significantly greater in cluster 1 than in clusters 2 and 3. Low back pain, therefore, does not appear to be homogeneous. Pain mechanisms relating to presentations of each subgroup were postulated. Future research may investigate prognoses and interventions tailored towards these subgroups. |
| first_indexed | 2025-11-14T09:01:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-40054 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:01:27Z |
| publishDate | 2015 |
| publisher | ELSEVIER SCIENCE BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-400542017-09-13T15:09:37Z Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis Rabey, Martin Slater, Helen O'Sullivan, Peter Beales, Darren Smith, Anne The objectives of this study were to explore the existence of subgroups in a cohort with chronic low back pain (n = 294) based on the results of multimodal sensory testing and profile subgroups on demographic, psychological, lifestyle, and general health factors. Bedside (2-point discrimination, brush, vibration and pinprick perception, temporal summation on repeated monofilament stimulation) and laboratory (mechanical detection threshold, pressure, heat and cold pain thresholds, conditioned pain modulation) sensory testing were examined at wrist and lumbar sites. Data were entered into principal component analysis, and 5 component scores were entered into latent class analysis. Three clusters, with different sensory characteristics, were derived. Cluster 1 (31.9%) was characterised by average to high temperature and pressure pain sensitivity. Cluster 2 (52.0%) was characterised by average to high pressure pain sensitivity. Cluster 3 (16.0%) was characterised by low temperature and pressure pain sensitivity. Temporal summation occurred significantly more frequently in cluster 1. Subgroups were profiled on pain intensity, disability, depression, anxiety, stress, life events, fear avoidance, catastrophizing, perception of the low back region, comorbidities, body mass index, multiple pain sites, sleep, and activity levels. Clusters 1 and 2 had a significantly greater proportion of female participants and higher depression and sleep disturbance scores than cluster 3. The proportion of participants undertaking <300 minutes per week of moderate activity was significantly greater in cluster 1 than in clusters 2 and 3. Low back pain, therefore, does not appear to be homogeneous. Pain mechanisms relating to presentations of each subgroup were postulated. Future research may investigate prognoses and interventions tailored towards these subgroups. 2015 Journal Article http://hdl.handle.net/20.500.11937/40054 10.1097/j.pain.0000000000000244 ELSEVIER SCIENCE BV restricted |
| spellingShingle | Rabey, Martin Slater, Helen O'Sullivan, Peter Beales, Darren Smith, Anne Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title | Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title_full | Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title_fullStr | Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title_full_unstemmed | Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title_short | Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| title_sort | somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis |
| url | http://hdl.handle.net/20.500.11937/40054 |