Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
Purpose: To determine the prognostic significance of FOXP3+ lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8+ and CD45RO+ lymphocyte densities. Patients and Methods: Tissue microarrays and immunohistochemistry were used to assess the den...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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American Society of Clinical Oncology
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/40045 |
| _version_ | 1848755759473491968 |
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| author | Salama, P. Phillips, M. Grieu, F. Morris, M. Zeps, Nikolajs Joseph, D. Platell, C. Iacopetta, B. |
| author_facet | Salama, P. Phillips, M. Grieu, F. Morris, M. Zeps, Nikolajs Joseph, D. Platell, C. Iacopetta, B. |
| author_sort | Salama, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To determine the prognostic significance of FOXP3+ lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8+ and CD45RO+ lymphocyte densities. Patients and Methods: Tissue microarrays and immunohistochemistry were used to assess the densities of CD8+, CD45RO+, and FOXP3+ lymphocytes in tumor tissue and normal colonic mucosa from 967 stage II and stage III colorectal cancers. These were evaluated for associations with histopathologic features and patient survival. Results: FOXP3+ Treg density was higher in tumor tissue compared with normal colonic mucosa, whereas CD8+ and CD45RO+ cell densities were lower. FOXP3+ Tregs were not associated with any histopathologic features, with the exception of tumor stage. Multivariate analysis showed that stage, vascular invasion, and FOXP3+ Treg density in normal and tumor tissue were independent prognostic indicators, but not CD8+ and CD45RO+. High FOXP3+ Treg density in normal mucosa was associated with worse prognosis (hazard ratio [HR] = 1.51; 95% CI, 1.07 to 2.13; P = .019). In contrast, a high density of FOXP3 + Tregs in tumor tissue was associated with improved survival (HR = 0.54; 95% CI, 0.38 to 0.77; P = .001). Conclusion: FOXP3+ Treg density in normal and tumor tissue had stronger prognostic significance in colorectal cancer compared with CD8+ and CD45RO+ lymphocytes. The finding of improved survival associated with a high density of tumor-infiltrating FOXP3+ Tregs in colorectal cancer contrasts with several other solid cancer types. The inclusion of FOXP3+ Treg density may help to improve the prognostication of early-stage colorectal cancer. © 2008 by American Society of Clinical Oncology. |
| first_indexed | 2025-11-14T09:01:25Z |
| format | Journal Article |
| id | curtin-20.500.11937-40045 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:01:25Z |
| publishDate | 2009 |
| publisher | American Society of Clinical Oncology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-400452023-08-02T06:39:08Z Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer Salama, P. Phillips, M. Grieu, F. Morris, M. Zeps, Nikolajs Joseph, D. Platell, C. Iacopetta, B. Purpose: To determine the prognostic significance of FOXP3+ lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8+ and CD45RO+ lymphocyte densities. Patients and Methods: Tissue microarrays and immunohistochemistry were used to assess the densities of CD8+, CD45RO+, and FOXP3+ lymphocytes in tumor tissue and normal colonic mucosa from 967 stage II and stage III colorectal cancers. These were evaluated for associations with histopathologic features and patient survival. Results: FOXP3+ Treg density was higher in tumor tissue compared with normal colonic mucosa, whereas CD8+ and CD45RO+ cell densities were lower. FOXP3+ Tregs were not associated with any histopathologic features, with the exception of tumor stage. Multivariate analysis showed that stage, vascular invasion, and FOXP3+ Treg density in normal and tumor tissue were independent prognostic indicators, but not CD8+ and CD45RO+. High FOXP3+ Treg density in normal mucosa was associated with worse prognosis (hazard ratio [HR] = 1.51; 95% CI, 1.07 to 2.13; P = .019). In contrast, a high density of FOXP3 + Tregs in tumor tissue was associated with improved survival (HR = 0.54; 95% CI, 0.38 to 0.77; P = .001). Conclusion: FOXP3+ Treg density in normal and tumor tissue had stronger prognostic significance in colorectal cancer compared with CD8+ and CD45RO+ lymphocytes. The finding of improved survival associated with a high density of tumor-infiltrating FOXP3+ Tregs in colorectal cancer contrasts with several other solid cancer types. The inclusion of FOXP3+ Treg density may help to improve the prognostication of early-stage colorectal cancer. © 2008 by American Society of Clinical Oncology. 2009 Journal Article http://hdl.handle.net/20.500.11937/40045 10.1200/JCO.2008.18.7229 American Society of Clinical Oncology restricted |
| spellingShingle | Salama, P. Phillips, M. Grieu, F. Morris, M. Zeps, Nikolajs Joseph, D. Platell, C. Iacopetta, B. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title | Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title_full | Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title_fullStr | Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title_full_unstemmed | Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title_short | Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer |
| title_sort | tumor-infiltrating foxp3+ t regulatory cells show strong prognostic significance in colorectal cancer |
| url | http://hdl.handle.net/20.500.11937/40045 |