Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates
Objectives: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding mobilization functions. Methods: Plasmid pWBG749 was labelled with Tn551 (pWBG...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Oxford University Press
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/3992 |
| _version_ | 1848744388461592576 |
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| author | O'Brien, Frances Ramsay, J. Monecke, S. Coombs, Geoffrey Robinson, O. Htet, Z. Alshaikh, F. Grubb, W. |
| author_facet | O'Brien, Frances Ramsay, J. Monecke, S. Coombs, Geoffrey Robinson, O. Htet, Z. Alshaikh, F. Grubb, W. |
| author_sort | O'Brien, Frances |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding mobilization functions. Methods: Plasmid pWBG749 was labelled with Tn551 (pWBG749e) to enable laboratory manipulation. Plasmid pWBG749e was conjugated into S. aureus of seven different lineages that harboured unrelated plasmids and mobilization experiments were performed. Plasmids were screened by EcoRI restriction and hybridization with probes prepared from unique pWBG749 conjugation genes. Results: Conjugative plasmids pWBG745, pWBG748 and pWBG749 belong to the same conjugative-plasmid family as the vancomycin resistance plasmid pBRZ01. Plasmid pWBG749e mobilized five unrelated plasmids. Mobilized plasmid pWBG744 is a pIB485-family plasmid that was also found in international S. aureus. Conclusions: Plasmid pWBG749e can mobilize unrelated S. aureus plasmids whose means of dissemination have not previously been understood. |
| first_indexed | 2025-11-14T06:00:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-3992 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:00:40Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-39922017-09-13T14:32:14Z Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates O'Brien, Frances Ramsay, J. Monecke, S. Coombs, Geoffrey Robinson, O. Htet, Z. Alshaikh, F. Grubb, W. Objectives: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding mobilization functions. Methods: Plasmid pWBG749 was labelled with Tn551 (pWBG749e) to enable laboratory manipulation. Plasmid pWBG749e was conjugated into S. aureus of seven different lineages that harboured unrelated plasmids and mobilization experiments were performed. Plasmids were screened by EcoRI restriction and hybridization with probes prepared from unique pWBG749 conjugation genes. Results: Conjugative plasmids pWBG745, pWBG748 and pWBG749 belong to the same conjugative-plasmid family as the vancomycin resistance plasmid pBRZ01. Plasmid pWBG749e mobilized five unrelated plasmids. Mobilized plasmid pWBG744 is a pIB485-family plasmid that was also found in international S. aureus. Conclusions: Plasmid pWBG749e can mobilize unrelated S. aureus plasmids whose means of dissemination have not previously been understood. 2015 Journal Article http://hdl.handle.net/20.500.11937/3992 10.1093/jac/dku454 Oxford University Press unknown |
| spellingShingle | O'Brien, Frances Ramsay, J. Monecke, S. Coombs, Geoffrey Robinson, O. Htet, Z. Alshaikh, F. Grubb, W. Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title | Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title_full | Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title_fullStr | Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title_full_unstemmed | Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title_short | Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| title_sort | staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates |
| url | http://hdl.handle.net/20.500.11937/3992 |