Can immunogenetics illuminate the diverse manifestations of respiratory infections?
Improved technologies for high-throughput genotyping and the establishment of well-defined cohorts prompted hope that polymorphisms would be discovered that define a patients' risk of respiratory disease or aid in diagnosis. Genetic pitfalls encountered in this quest include genotyping errors,...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/39758 |
| _version_ | 1848755678928175104 |
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| author | Affandi, J. Price, Patricia Waterer, G. |
| author_facet | Affandi, J. Price, Patricia Waterer, G. |
| author_sort | Affandi, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Improved technologies for high-throughput genotyping and the establishment of well-defined cohorts prompted hope that polymorphisms would be discovered that define a patients' risk of respiratory disease or aid in diagnosis. Genetic pitfalls encountered in this quest include genotyping errors, ethnic differences and linkage dysequilibrium. Differences in the definition of the disease phenotype also create discrepancies, so immunogenetic testing has not yet reached the clinic. However, associations between a polymorphism and a disease phenotype place the gene or one in linkage dysequilibrium on the path to the disease. Here we review studies of immune-related genes that are illuminating the immunopathogenesis of community-acquired pneumonia and mycobacterial infections. © 2010 The Author(s). |
| first_indexed | 2025-11-14T09:00:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-39758 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:00:08Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-397582017-09-13T15:05:25Z Can immunogenetics illuminate the diverse manifestations of respiratory infections? Affandi, J. Price, Patricia Waterer, G. Improved technologies for high-throughput genotyping and the establishment of well-defined cohorts prompted hope that polymorphisms would be discovered that define a patients' risk of respiratory disease or aid in diagnosis. Genetic pitfalls encountered in this quest include genotyping errors, ethnic differences and linkage dysequilibrium. Differences in the definition of the disease phenotype also create discrepancies, so immunogenetic testing has not yet reached the clinic. However, associations between a polymorphism and a disease phenotype place the gene or one in linkage dysequilibrium on the path to the disease. Here we review studies of immune-related genes that are illuminating the immunopathogenesis of community-acquired pneumonia and mycobacterial infections. © 2010 The Author(s). 2010 Journal Article http://hdl.handle.net/20.500.11937/39758 10.1177/1753465810371484 restricted |
| spellingShingle | Affandi, J. Price, Patricia Waterer, G. Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title | Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title_full | Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title_fullStr | Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title_full_unstemmed | Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title_short | Can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| title_sort | can immunogenetics illuminate the diverse manifestations of respiratory infections? |
| url | http://hdl.handle.net/20.500.11937/39758 |