Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease
IL-5 and interferon-? responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Mary Ann Liebert, Inc.
2010
|
| Online Access: | http://hdl.handle.net/20.500.11937/3963 |
| _version_ | 1848744379992244224 |
|---|---|
| author | Oliver, B. Elliott, J. Saphonn, V. Vun, M. French, M. Price, Patricia |
| author_facet | Oliver, B. Elliott, J. Saphonn, V. Vun, M. French, M. Price, Patricia |
| author_sort | Oliver, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | IL-5 and interferon-? responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) associated with M. tuberculosis after starting antiretroviral therapy (ART). Interferon-? levels were constant on ART, whilst IL-5 levels generally rose over time. We suggest that increased IL-5 production reflects a recovery of CD4 + T cell function and that a Th1/Th2 imbalance is not associated with increased susceptibility to M. tuberculosis disease or IRD associated with M. tuberculosis upon starting ART. Copyright © 2010, Mary Ann Liebert, Inc. |
| first_indexed | 2025-11-14T06:00:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-3963 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:00:32Z |
| publishDate | 2010 |
| publisher | Mary Ann Liebert, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-39632017-09-13T14:30:54Z Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease Oliver, B. Elliott, J. Saphonn, V. Vun, M. French, M. Price, Patricia IL-5 and interferon-? responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) associated with M. tuberculosis after starting antiretroviral therapy (ART). Interferon-? levels were constant on ART, whilst IL-5 levels generally rose over time. We suggest that increased IL-5 production reflects a recovery of CD4 + T cell function and that a Th1/Th2 imbalance is not associated with increased susceptibility to M. tuberculosis disease or IRD associated with M. tuberculosis upon starting ART. Copyright © 2010, Mary Ann Liebert, Inc. 2010 Journal Article http://hdl.handle.net/20.500.11937/3963 10.1089/aid.2010.0004 Mary Ann Liebert, Inc. restricted |
| spellingShingle | Oliver, B. Elliott, J. Saphonn, V. Vun, M. French, M. Price, Patricia Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title | Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title_full | Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title_fullStr | Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title_full_unstemmed | Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title_short | Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| title_sort | interferon-? and il-5 production correlate directly in hiv patients co-infected with mycobacterium tuberculosis with or without immune restoration disease |
| url | http://hdl.handle.net/20.500.11937/3963 |