Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety
The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(a-D-glucurono-a–manno-ß-D-manno-ß-D-gluco), (a-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mecha...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Elsevier BV
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/39486 |
| _version_ | 1848755603907805184 |
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| author | Solah, Vicky Brand-Miller, J. Atkinson, F. Gahler, R. Kacinik, V. Lyon, M. Wood, S. |
| author_facet | Solah, Vicky Brand-Miller, J. Atkinson, F. Gahler, R. Kacinik, V. Lyon, M. Wood, S. |
| author_sort | Solah, Vicky |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(a-D-glucurono-a–manno-ß-D-manno-ß-D-gluco), (a-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7,P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control. |
| first_indexed | 2025-11-14T08:58:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-39486 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:58:56Z |
| publishDate | 2014 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-394862017-09-13T14:24:12Z Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety Solah, Vicky Brand-Miller, J. Atkinson, F. Gahler, R. Kacinik, V. Lyon, M. Wood, S. satiety fibre dose The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(a-D-glucurono-a–manno-ß-D-manno-ß-D-gluco), (a-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7,P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control. 2014 Journal Article http://hdl.handle.net/20.500.11937/39486 10.1016/j.appet.2014.02.021 Elsevier BV unknown |
| spellingShingle | satiety fibre dose Solah, Vicky Brand-Miller, J. Atkinson, F. Gahler, R. Kacinik, V. Lyon, M. Wood, S. Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title_full | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title_fullStr | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title_full_unstemmed | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title_short | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety |
| title_sort | dose–response effect of a novel functional fibre, polyglycoplex®, pgx®, on satiety |
| topic | satiety fibre dose |
| url | http://hdl.handle.net/20.500.11937/39486 |