Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

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Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the trea...

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Bibliographic Details
Main Authors:	Shanmugam, M., Manu, K., Ong, T., Ramachandran, L., Surana, R., Bist, P., Lim, L., Kumar, Alan Prem, Hui, K., Sethi, G.
Format:	Journal Article
Published:	2011
Online Access:	http://hdl.handle.net/20.500.11937/39382

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