Perinatal and childhood origins of cardiovascular disease
Background: Features of the metabolic syndrome comprise a major risk for cardiovascular disease and will increase in prevalence with rising childhood obesity. We sought to identify early life influences on development of obesity, hypertension and dyslipidemia in children.Methods and results: Cluster...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Nature Publishing Group
2007
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| Online Access: | http://hdl.handle.net/20.500.11937/39329 |
| _version_ | 1848755561888219136 |
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| author | Huang, R. Burke, V. Newnham, J. Stanley, F. Kendall, Garth Landau, L. Oddy, Wendy Blake, K. Palmer, L. Beilin, L. |
| author_facet | Huang, R. Burke, V. Newnham, J. Stanley, F. Kendall, Garth Landau, L. Oddy, Wendy Blake, K. Palmer, L. Beilin, L. |
| author_sort | Huang, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Features of the metabolic syndrome comprise a major risk for cardiovascular disease and will increase in prevalence with rising childhood obesity. We sought to identify early life influences on development of obesity, hypertension and dyslipidemia in children.Methods and results: Cluster analysis was used on a subset of a longitudinal Australian birth cohort who had blood samples at age 8 (n=406). A quarter of these 8-year-olds fell into a cluster with higher body mass index, blood pressure (BP), more adverse lipid profile and a trend to higher serum glucose resembling adult metabolic syndrome. There was a U-shaped relationship between percentage of expected birth weight (PEBW) and likelihood of being in the high-risk cluster. The high-risk cluster had elevated BP and weight as early as 1 and 3 years old. Increased likelihood of the high-risk cluster group occurred with greatest weight gain from 1 to 8 years old (odds ratio (OR)=1.4, 95% confidence interval (CI)=1.3?1.5/kg) and if mothers smoked during pregnancy (OR=1.82, CI=1.05?3.2). Risk was lower if children were breast fed for 4 months (OR=0.6, 95% CI=0.37?0.97). Newborns in the upper two quintiles for PEBW born to mothers who smoked throughout pregnancy were at greatest risk (OR=14.0, 95% CI=3.8?51.1) compared to the nadir PEBW quintile of non-smokers.Conclusion: A U-shaped relationship between birth weight and several components of the metabolic syndrome was confirmed in a contemporary, well-nourished Western population of full-term newborns, but post-natal weight gain was the dominant factor associated with the high-risk cluster. There was a prominence of higher as well as lowest birth weights in those at risk. Future health programs should focus on both pre- and post-natal factors (reducing excess childhood weight gain and smoking during pregnancy), and possibly the greatest benefits may arise from targeting the heaviest, as well as lightest newborns, especially with a history of maternal smoking during pregnancy. |
| first_indexed | 2025-11-14T08:58:16Z |
| format | Journal Article |
| id | curtin-20.500.11937-39329 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:58:16Z |
| publishDate | 2007 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-393292019-02-19T05:35:17Z Perinatal and childhood origins of cardiovascular disease Huang, R. Burke, V. Newnham, J. Stanley, F. Kendall, Garth Landau, L. Oddy, Wendy Blake, K. Palmer, L. Beilin, L. breast feeding pediatrics smoking metabolic syndrome maternal smoking birth weight Background: Features of the metabolic syndrome comprise a major risk for cardiovascular disease and will increase in prevalence with rising childhood obesity. We sought to identify early life influences on development of obesity, hypertension and dyslipidemia in children.Methods and results: Cluster analysis was used on a subset of a longitudinal Australian birth cohort who had blood samples at age 8 (n=406). A quarter of these 8-year-olds fell into a cluster with higher body mass index, blood pressure (BP), more adverse lipid profile and a trend to higher serum glucose resembling adult metabolic syndrome. There was a U-shaped relationship between percentage of expected birth weight (PEBW) and likelihood of being in the high-risk cluster. The high-risk cluster had elevated BP and weight as early as 1 and 3 years old. Increased likelihood of the high-risk cluster group occurred with greatest weight gain from 1 to 8 years old (odds ratio (OR)=1.4, 95% confidence interval (CI)=1.3?1.5/kg) and if mothers smoked during pregnancy (OR=1.82, CI=1.05?3.2). Risk was lower if children were breast fed for 4 months (OR=0.6, 95% CI=0.37?0.97). Newborns in the upper two quintiles for PEBW born to mothers who smoked throughout pregnancy were at greatest risk (OR=14.0, 95% CI=3.8?51.1) compared to the nadir PEBW quintile of non-smokers.Conclusion: A U-shaped relationship between birth weight and several components of the metabolic syndrome was confirmed in a contemporary, well-nourished Western population of full-term newborns, but post-natal weight gain was the dominant factor associated with the high-risk cluster. There was a prominence of higher as well as lowest birth weights in those at risk. Future health programs should focus on both pre- and post-natal factors (reducing excess childhood weight gain and smoking during pregnancy), and possibly the greatest benefits may arise from targeting the heaviest, as well as lightest newborns, especially with a history of maternal smoking during pregnancy. 2007 Journal Article http://hdl.handle.net/20.500.11937/39329 10.1038/sj.ijo.0803394 Nature Publishing Group restricted |
| spellingShingle | breast feeding pediatrics smoking metabolic syndrome maternal smoking birth weight Huang, R. Burke, V. Newnham, J. Stanley, F. Kendall, Garth Landau, L. Oddy, Wendy Blake, K. Palmer, L. Beilin, L. Perinatal and childhood origins of cardiovascular disease |
| title | Perinatal and childhood origins of cardiovascular disease |
| title_full | Perinatal and childhood origins of cardiovascular disease |
| title_fullStr | Perinatal and childhood origins of cardiovascular disease |
| title_full_unstemmed | Perinatal and childhood origins of cardiovascular disease |
| title_short | Perinatal and childhood origins of cardiovascular disease |
| title_sort | perinatal and childhood origins of cardiovascular disease |
| topic | breast feeding pediatrics smoking metabolic syndrome maternal smoking birth weight |
| url | http://hdl.handle.net/20.500.11937/39329 |