Effect of coadministered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria

QR Code

Effect of coadministered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria

Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity. There have been no studies of these potential effects in the pediatric age group. The tolerability, safety, efficacy, and pharmacokinetics...

Full description

Bibliographic Details
Main Authors:	Moore, Brioni, Benjamin, J., Salman, S., Griffin, S., Ginny, E., Page-Sharp, Madhu, Robinson, L., Siba, P., Batty, Kevin, Mueller, I., Davis, T.
Format:	Journal Article
Published:	American Society for Microbiology 2014
Online Access:	http://hdl.handle.net/20.500.11937/3926

Similar Items

Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria
by: Salman, S., et al.
Published: (2012)

Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women
by: Moore, B., et al.
Published: (2016)

Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women
by: Benjamin, J., et al.
Published: (2015)

Population Pharmacokinetics of Artemether, Lumefantrine, and Their Respective Metabolites in Papua New Guinean Children with Uncomplicated Malaria
by: Salman, S., et al.
Published: (2011)

PHARMACOKINETICS OF TRANSFER OF PIPERAQUINE INTO THE BREAST MILK OF PAPUA NEW GUINEAN MOTHERS
by: Moore, B., et al.
Published: (2015)

Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria
by: Karunajeewa, H., et al.
Published: (2008)

Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model
by: Moore, Brioni, et al.
Published: (2008)

Pharmacokinetic properties of single-dose primaquine in Papua New Guinean children: Feasibility of abbreviated high-dose regimens for radical cure of vivax malaria
by: Moore, Brioni, et al.
Published: (2014)

Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria
by: Karl, S., et al.
Published: (2016)

Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study
by: Batty, Kevin, et al.
Published: (2012)

Comparison of an assumed versus measured leucocyte count in parasite density calculations in Papua New Guinean children with uncomplicated malaria
by: Laman, M., et al.
Published: (2014)

Toxicology and pharmacokinetics of piperaquine in mice
by: Batty, Kevin, et al.
Published: (2008)

Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers
by: Moore, B., et al.
Published: (2015)

Pharmacokinetics of dihydroartemisinin in a murine malaria model
by: Batty, Kevin, et al.
Published: (2008)

Cost-effectiveness of artemisinin-naphthoquine versus artemether-lumefantrine for the treatment of uncomplicated malaria in Papua New Guinean children
by: Moore, Brioni, et al.
Published: (2017)

Artemisinin-Naphthoquine versus Artemether-Lumefantrine for Uncomplicated Malaria in Papua New Guinean Children: An Open-Label Randomized Trial
by: Laman, M., et al.
Published: (2014)

Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: A six months post-treatment follow-up study
by: Laman, M., et al.
Published: (2015)

Piperaquine pharmacodynamics and parasite viability in a murine malaria model
by: Moore, Broni, et al.
Published: (2009)

Investigation of reproductive toxicology in piperaquine in mice
by: Batty, Kevin, et al.
Published: (2010)

Pharmacokinetics, Pharmacodynamics and Allometric Scaling of Chloroquine in a Murine Malaria Model
by: Moore, Brioni, et al.
Published: (2011)

Validation of a dried blood spot ceftriaxone assay in Papua New Guinean children with severe bacterial infections
by: Mukap, M., et al.
Published: (2018)

Meningeal inflammation increases cerebrospinal fluid artemether concentrations in Papua New Guinean children treated with intramuscular artemether
by: Manning, L., et al.
Published: (2011)

Plasmodium berghei: Parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model
by: Moore, Brioni, et al.
Published: (2008)

Liver injury in uncomplicated malaria: an overlooked phenomenon.
by: Moore, Brioni
Published: (2018)

Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria
by: Patel, K., et al.
Published: (2013)

Electrocardiographic safety of repeated monthly dihydroartemisinin-piperaquine as a candidate for mass drug administration
by: Millat-Martínez, P., et al.
Published: (2018)

Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: A tolerability, safety, and preliminary efficacy study
by: Benjamin, J., et al.
Published: (2012)

Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin
by: Gibbons, Peter, et al.
Published: (2007)

Comparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria
by: Karl, S., et al.
Published: (2014)

Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy
by: Karl, S., et al.
Published: (2015)

Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy
by: Karunajeewa, H., et al.
Published: (2010)

Optimal antimalarial dose regimens for sulfadoxine-pyrimethamine with or without azithromycin in pregnancy based on population pharmacokinetic modeling
by: Salman, S., et al.
Published: (2017)

Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women
by: Karunajeewa, H., et al.
Published: (2009)

Use of quantitative pharmacology tools to improve malaria treatments
by: Davis, T., et al.
Published: (2015)

Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling
by: Salman, S., et al.
Published: (2017)

Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial
by: Pomat, William, et al.
Published: (2013)

Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations
by: Chambers, J., et al.
Published: (2018)

Anti-inflammatory and antibacterial effects of kinos from Australian and Papua New Guinean Eucalyptus species
by: Mungkaje, Martha Yahimbu
Published: (2015)

Improving the Solubility and Bioavailability of Dihydroartemisinin by Solid Dispersions and Inclusion Complexes
by: Ansari, M., et al.
Published: (2011)

Population pharmacokinetic study of ceftriaxone in elderly patients, using cystatin C-based estimates of renal function to account for frailty
by: Tan, S.J., et al.
Published: (2020)

Cannot write session to /tmp/vufind_sessions/sess_boc59oigaig4qtgahp4sj462k9