Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers
Aims: While excessive sitting time is related adversely to cardio-metabolic health, it is unknown whether standing is a suitable replacement activity or whether ambulatory movement is required. Using isotemporal substitution analyses, we modelled cross-sectional associations with cardio-metabolic ri...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/38881 |
| _version_ | 1848755439757426688 |
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| author | Healy, Genevieve Winkler, E. Owen, N. Anuradha, S. Dunstan, D. |
| author_facet | Healy, Genevieve Winkler, E. Owen, N. Anuradha, S. Dunstan, D. |
| author_sort | Healy, Genevieve |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aims: While excessive sitting time is related adversely to cardio-metabolic health, it is unknown whether standing is a suitable replacement activity or whether ambulatory movement is required. Using isotemporal substitution analyses, we modelled cross-sectional associations with cardio-metabolic risk biomarkers of reallocating time (2 h/day) from sitting to standing or to stepping.Methods and results: A subsample of participants from the 2011/12 Australian Diabetes, Obesity, and Lifestyle Study wore the posture-based activPAL3 monitor [36–80 years (mean 57.9, SD 9.9 years); 57% women; n = 698 with data]. Associations of activPAL3-derived mean daily time sitting/lying (sitting), standing and stepping with body mass index (BMI), waist circumference, blood pressure, HbA1c, fasting glucose and lipids (high-density lipoprotein-, HDL, and low-density lipoprotein-cholesterol, total/HDL-cholesterol ratio, and triglycerides), and 2-h plasma glucose were examined. Adjusted for relevant confounders, sitting-to-standing reallocations were only significantly (P < 0.05) associated with approximately 2% lower fasting plasma glucose, 11% lower triglycerides, 6% lower total/HDL-cholesterol ratio, and 0.06 mmol/L higher HDL-cholesterol per 2 h/day. Sitting-to-stepping reallocations were only significantly associated with approximately 11% lower BMI, 7.5 cm lower waist circumference, 11% lower 2-h plasma glucose, 14% lower triglycerides, and 0.10 mmol/L higher HDL-cholesterol per 2 h/ day, while standing-to-stepping reallocations were only significantly associated with ∼10% lower BMI, 7 cm lower waist circumference, and 11% lower 2-h plasma glucose.Conclusion: Findings suggested that sitting-reduction strategies targeting increased standing, stepping, or both, may benefit cardio-metabolic health. Standing is a simple alternative to sitting, and requires further examination in prospective and intervention studies. |
| first_indexed | 2025-11-14T08:56:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-38881 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:56:20Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-388812017-09-13T14:15:06Z Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers Healy, Genevieve Winkler, E. Owen, N. Anuradha, S. Dunstan, D. Aims: While excessive sitting time is related adversely to cardio-metabolic health, it is unknown whether standing is a suitable replacement activity or whether ambulatory movement is required. Using isotemporal substitution analyses, we modelled cross-sectional associations with cardio-metabolic risk biomarkers of reallocating time (2 h/day) from sitting to standing or to stepping.Methods and results: A subsample of participants from the 2011/12 Australian Diabetes, Obesity, and Lifestyle Study wore the posture-based activPAL3 monitor [36–80 years (mean 57.9, SD 9.9 years); 57% women; n = 698 with data]. Associations of activPAL3-derived mean daily time sitting/lying (sitting), standing and stepping with body mass index (BMI), waist circumference, blood pressure, HbA1c, fasting glucose and lipids (high-density lipoprotein-, HDL, and low-density lipoprotein-cholesterol, total/HDL-cholesterol ratio, and triglycerides), and 2-h plasma glucose were examined. Adjusted for relevant confounders, sitting-to-standing reallocations were only significantly (P < 0.05) associated with approximately 2% lower fasting plasma glucose, 11% lower triglycerides, 6% lower total/HDL-cholesterol ratio, and 0.06 mmol/L higher HDL-cholesterol per 2 h/day. Sitting-to-stepping reallocations were only significantly associated with approximately 11% lower BMI, 7.5 cm lower waist circumference, 11% lower 2-h plasma glucose, 14% lower triglycerides, and 0.10 mmol/L higher HDL-cholesterol per 2 h/ day, while standing-to-stepping reallocations were only significantly associated with ∼10% lower BMI, 7 cm lower waist circumference, and 11% lower 2-h plasma glucose.Conclusion: Findings suggested that sitting-reduction strategies targeting increased standing, stepping, or both, may benefit cardio-metabolic health. Standing is a simple alternative to sitting, and requires further examination in prospective and intervention studies. 2015 Journal Article http://hdl.handle.net/20.500.11937/38881 10.1093/eurheartj/ehv308 unknown |
| spellingShingle | Healy, Genevieve Winkler, E. Owen, N. Anuradha, S. Dunstan, D. Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title | Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title_full | Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title_fullStr | Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title_full_unstemmed | Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title_short | Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| title_sort | replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers |
| url | http://hdl.handle.net/20.500.11937/38881 |