Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy
Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy.In this paper, core–shell structured titanium dioxide–silica (TiO2–SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photore...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier BV
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/38817 |
| _version_ | 1848755422641520640 |
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| author | Feng, Xiaohui Zhang, Shaokun Lou, Xia |
| author_facet | Feng, Xiaohui Zhang, Shaokun Lou, Xia |
| author_sort | Feng, Xiaohui |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy.In this paper, core–shell structured titanium dioxide–silica (TiO2–SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicityand photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929). |
| first_indexed | 2025-11-14T08:56:03Z |
| format | Journal Article |
| id | curtin-20.500.11937-38817 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:56:03Z |
| publishDate | 2013 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-388172017-09-13T14:17:44Z Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy Feng, Xiaohui Zhang, Shaokun Lou, Xia Photo-killing agent Silica coating Photodynamic therapy TiO2 nanoparticles Silica-coated TiO2 nanoparticles Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy.In this paper, core–shell structured titanium dioxide–silica (TiO2–SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicityand photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929). 2013 Journal Article http://hdl.handle.net/20.500.11937/38817 10.1016/j.colsurfb.2013.02.007 Elsevier BV fulltext |
| spellingShingle | Photo-killing agent Silica coating Photodynamic therapy TiO2 nanoparticles Silica-coated TiO2 nanoparticles Feng, Xiaohui Zhang, Shaokun Lou, Xia Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title | Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title_full | Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title_fullStr | Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title_full_unstemmed | Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title_short | Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy |
| title_sort | controlling silica coating thickness on tio2 nanoparticles for effective photodynamic therapy |
| topic | Photo-killing agent Silica coating Photodynamic therapy TiO2 nanoparticles Silica-coated TiO2 nanoparticles |
| url | http://hdl.handle.net/20.500.11937/38817 |