Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study
Objective. The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA. Methods. A total of 150 RA patients were assessed for cardiorespiratory f...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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S. Karger AG
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/3868 |
| _version_ | 1848744350881677312 |
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| author | Metsios, G. Koutedakis, Y. Veldhuijzen van Zanten, J. Stavropoulos-Kalinoglou, A. Vitalis, P. Duda, J. Ntoumanis, Nikos Rouse, P. Kitas, G. |
| author_facet | Metsios, G. Koutedakis, Y. Veldhuijzen van Zanten, J. Stavropoulos-Kalinoglou, A. Vitalis, P. Duda, J. Ntoumanis, Nikos Rouse, P. Kitas, G. |
| author_sort | Metsios, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective. The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA. Methods. A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases. Results. Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity. Conclusion. VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA. |
| first_indexed | 2025-11-14T06:00:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-3868 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:00:04Z |
| publishDate | 2015 |
| publisher | S. Karger AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-38682020-07-23T08:31:40Z Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study Metsios, G. Koutedakis, Y. Veldhuijzen van Zanten, J. Stavropoulos-Kalinoglou, A. Vitalis, P. Duda, J. Ntoumanis, Nikos Rouse, P. Kitas, G. Objective. The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA. Methods. A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases. Results. Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity. Conclusion. VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA. 2015 Journal Article http://hdl.handle.net/20.500.11937/3868 10.1093/rheumatology/kev035 S. Karger AG fulltext |
| spellingShingle | Metsios, G. Koutedakis, Y. Veldhuijzen van Zanten, J. Stavropoulos-Kalinoglou, A. Vitalis, P. Duda, J. Ntoumanis, Nikos Rouse, P. Kitas, G. Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title | Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title_full | Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title_fullStr | Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title_full_unstemmed | Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title_short | Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| title_sort | cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study |
| url | http://hdl.handle.net/20.500.11937/3868 |