The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults
Objectives: To determine the acute effect of a mild cold exposure on thermoregulatory thermogenesis and the role of circulating irisin in the process. Methods: We studied 22 adults (9 males, 13 females) aged 57.7 ± 10.07 years and body mass index 27.8 ± 4.52 kg/m2. Participants experienced a 90-min...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/38625 |
| _version_ | 1848755371108204544 |
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| author | Calton, E. Soares, Mario James, A. Woodman, R. |
| author_facet | Calton, E. Soares, Mario James, A. Woodman, R. |
| author_sort | Calton, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To determine the acute effect of a mild cold exposure on thermoregulatory thermogenesis and the role of circulating irisin in the process. Methods: We studied 22 adults (9 males, 13 females) aged 57.7 ± 10.07 years and body mass index 27.8 ± 4.52 kg/m2. Participants experienced a 90-min exposure to 20°C and 25°C in a randomized cross-over design. Resting metabolic rate (RMR), forearm to finger-tip gradient (FFG), blood pressure (BP), in-the-ear temperature (IET), and fasting bloods were measured on each occasion. Results: There were significant increases in FFG [mean ± SD: +3.8 ± 3.0°C, P < 0.001], systolic blood pressure (SBP) [+8 ± 13 mm Hg, P = 0.015], and diastolic blood pressure (DBP) [+4 ± 6 mm Hg, P = 0.005] and decreases in IET [−0.24 ± 0.29°C, P = 0.001]. Overall, RMR [+190 ± 570 kJ/d, P = 0.135], irisin, glucose or insulin did not differ between temperatures. There were no significant between-gender differences, but males significantly increased SBP (+12 ± 16, P = 0.02) and DBP (+6 ± 7, P = 0.02) with decreases in heart rate (−4 ± 3, P = 0.002), while females did not. Moreover men had approximately 50% higher thermogenic response while women had approximately 25% greater vasoconstrictor response. Adjusted for age, gender, insulin sensitivity, and body composition, fold changes in irisin were inversely related to respiratory quotient (r= −0.54, P = 0.048), while IET was related to FFG (r= −0.55, P = 0.043). Conclusions: Mild cold exposure increased vasoconstriction with a drop in IET and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering. A potential gender bias in thermoregulation was noted. |
| first_indexed | 2025-11-14T08:55:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-38625 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:55:14Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-386252017-09-13T15:36:42Z The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults Calton, E. Soares, Mario James, A. Woodman, R. Objectives: To determine the acute effect of a mild cold exposure on thermoregulatory thermogenesis and the role of circulating irisin in the process. Methods: We studied 22 adults (9 males, 13 females) aged 57.7 ± 10.07 years and body mass index 27.8 ± 4.52 kg/m2. Participants experienced a 90-min exposure to 20°C and 25°C in a randomized cross-over design. Resting metabolic rate (RMR), forearm to finger-tip gradient (FFG), blood pressure (BP), in-the-ear temperature (IET), and fasting bloods were measured on each occasion. Results: There were significant increases in FFG [mean ± SD: +3.8 ± 3.0°C, P < 0.001], systolic blood pressure (SBP) [+8 ± 13 mm Hg, P = 0.015], and diastolic blood pressure (DBP) [+4 ± 6 mm Hg, P = 0.005] and decreases in IET [−0.24 ± 0.29°C, P = 0.001]. Overall, RMR [+190 ± 570 kJ/d, P = 0.135], irisin, glucose or insulin did not differ between temperatures. There were no significant between-gender differences, but males significantly increased SBP (+12 ± 16, P = 0.02) and DBP (+6 ± 7, P = 0.02) with decreases in heart rate (−4 ± 3, P = 0.002), while females did not. Moreover men had approximately 50% higher thermogenic response while women had approximately 25% greater vasoconstrictor response. Adjusted for age, gender, insulin sensitivity, and body composition, fold changes in irisin were inversely related to respiratory quotient (r= −0.54, P = 0.048), while IET was related to FFG (r= −0.55, P = 0.043). Conclusions: Mild cold exposure increased vasoconstriction with a drop in IET and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering. A potential gender bias in thermoregulation was noted. 2016 Journal Article http://hdl.handle.net/20.500.11937/38625 10.1002/ajhb.22853 fulltext |
| spellingShingle | Calton, E. Soares, Mario James, A. Woodman, R. The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title | The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title_full | The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title_fullStr | The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title_full_unstemmed | The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title_short | The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| title_sort | potential role of irisin in the thermoregulatory responses to mild cold exposure in adults |
| url | http://hdl.handle.net/20.500.11937/38625 |