Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China
Background: Ovarian cancer is an important neoplasm that is difficult to diagnose and treat; therefore, prevention is the preferable strategy. Growing evidence indicates a protective effect of breastfeeding on ovarian cancer risk. Objective: The objective was to investigate the association between l...
| Main Authors: | , , , |
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| Format: | Journal Article |
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American Society for Nutrition
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/3846 |
| _version_ | 1848744343071883264 |
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| author | Su, D. Pasalich, Maria Lee, Andy Binns, Colin |
| author_facet | Su, D. Pasalich, Maria Lee, Andy Binns, Colin |
| author_sort | Su, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Ovarian cancer is an important neoplasm that is difficult to diagnose and treat; therefore, prevention is the preferable strategy. Growing evidence indicates a protective effect of breastfeeding on ovarian cancer risk. Objective: The objective was to investigate the association between lactation and the risk of ovarian cancer among southern Chinese women. Design: A case-control study was undertaken in Guangzhou, Guangdong Province, between August 2006 and July 2008. A validated and reliable questionnaire was used to obtain information on the months of lactation and number of children breastfed in a sample of 493 incident ovarian cancer patients and 472 hospital-based controls (mean age: 59 y). Logistic regression analyses were performed to assess the association between breastfeeding and the risk of ovarian cancer. Results: Significant inverse dose-response relations were found for both duration of lactation and the number of children breastfed. The adjusted ORs were 0.09 (95% CI: 0.04, 0.19) for women with ≥31 mo of total lactation and those with ≤10 mo of lactation and 0.38 (95% CI: 0.27, 0.55) for women with ≥3 children breastfed compared with those with one child breastfed. Conclusion: Prolonged lactation is associated with a lower risk of ovarian cancer in parous Chinese women. |
| first_indexed | 2025-11-14T05:59:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-3846 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:59:57Z |
| publishDate | 2013 |
| publisher | American Society for Nutrition |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-38462017-09-13T16:06:54Z Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China Su, D. Pasalich, Maria Lee, Andy Binns, Colin Background: Ovarian cancer is an important neoplasm that is difficult to diagnose and treat; therefore, prevention is the preferable strategy. Growing evidence indicates a protective effect of breastfeeding on ovarian cancer risk. Objective: The objective was to investigate the association between lactation and the risk of ovarian cancer among southern Chinese women. Design: A case-control study was undertaken in Guangzhou, Guangdong Province, between August 2006 and July 2008. A validated and reliable questionnaire was used to obtain information on the months of lactation and number of children breastfed in a sample of 493 incident ovarian cancer patients and 472 hospital-based controls (mean age: 59 y). Logistic regression analyses were performed to assess the association between breastfeeding and the risk of ovarian cancer. Results: Significant inverse dose-response relations were found for both duration of lactation and the number of children breastfed. The adjusted ORs were 0.09 (95% CI: 0.04, 0.19) for women with ≥31 mo of total lactation and those with ≤10 mo of lactation and 0.38 (95% CI: 0.27, 0.55) for women with ≥3 children breastfed compared with those with one child breastfed. Conclusion: Prolonged lactation is associated with a lower risk of ovarian cancer in parous Chinese women. 2013 Journal Article http://hdl.handle.net/20.500.11937/3846 10.3945/ajcn.112.044719 American Society for Nutrition unknown |
| spellingShingle | Su, D. Pasalich, Maria Lee, Andy Binns, Colin Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title | Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title_full | Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title_fullStr | Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title_full_unstemmed | Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title_short | Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China |
| title_sort | ovarian cancer risk is reduced by prolonged lactation: a case-control study in southern china |
| url | http://hdl.handle.net/20.500.11937/3846 |