Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
© 2016 The Authors. Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DO...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/38338 |
| _version_ | 1848755293703372800 |
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| author | Manchun, S. Dass, Crispin Sriamornsak, P. |
| author_facet | Manchun, S. Dass, Crispin Sriamornsak, P. |
| author_sort | Manchun, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 The Authors. Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25?°C/60% RH) and long-term (5?°C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5?°C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p?>?0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5?°C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5?°C. |
| first_indexed | 2025-11-14T08:54:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-38338 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:54:00Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-383382017-09-13T14:11:36Z Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin Manchun, S. Dass, Crispin Sriamornsak, P. © 2016 The Authors. Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25?°C/60% RH) and long-term (5?°C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5?°C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p?>?0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5?°C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5?°C. 2016 Journal Article http://hdl.handle.net/20.500.11937/38338 10.1016/j.ajps.2015.09.006 unknown |
| spellingShingle | Manchun, S. Dass, Crispin Sriamornsak, P. Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title_full | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title_fullStr | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title_full_unstemmed | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title_short | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
| title_sort | stability of freeze-dried ph-responsive dextrin nanogels containing doxorubicin |
| url | http://hdl.handle.net/20.500.11937/38338 |