Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings
Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
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Cambridge University Press
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/38180 |
| _version_ | 1848755250656182272 |
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| author | Knox, J. Van Rijen, M. Uhlemann, A. Miller, M. Hafer, C. Vavagiakis, P. Shi, Q. Johnson, P. Coombs, Geoffrey Kluytmans-Van Den Bergh, M. Kluytmans, J. Bennett, C. Lowy, F. |
| author_facet | Knox, J. Van Rijen, M. Uhlemann, A. Miller, M. Hafer, C. Vavagiakis, P. Shi, Q. Johnson, P. Coombs, Geoffrey Kluytmans-Van Den Bergh, M. Kluytmans, J. Bennett, C. Lowy, F. |
| author_sort | Knox, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (P < 0·01) and the percent of household members aged <18 years (P < 0·01) were independently associated with transmission. Targeted decolonization strategies could be used across geographical settings to limit household MRSA transmission. |
| first_indexed | 2025-11-14T08:53:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-38180 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:53:19Z |
| publishDate | 2015 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-381802018-03-29T09:07:09Z Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings Knox, J. Van Rijen, M. Uhlemann, A. Miller, M. Hafer, C. Vavagiakis, P. Shi, Q. Johnson, P. Coombs, Geoffrey Kluytmans-Van Den Bergh, M. Kluytmans, J. Bennett, C. Lowy, F. Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (P < 0·01) and the percent of household members aged <18 years (P < 0·01) were independently associated with transmission. Targeted decolonization strategies could be used across geographical settings to limit household MRSA transmission. 2015 Journal Article http://hdl.handle.net/20.500.11937/38180 10.1017/S0950268814000983 Cambridge University Press restricted |
| spellingShingle | Knox, J. Van Rijen, M. Uhlemann, A. Miller, M. Hafer, C. Vavagiakis, P. Shi, Q. Johnson, P. Coombs, Geoffrey Kluytmans-Van Den Bergh, M. Kluytmans, J. Bennett, C. Lowy, F. Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title | Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title_full | Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title_fullStr | Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title_full_unstemmed | Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title_short | Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: A pooled analysis of primary data from three studies across international settings |
| title_sort | community-associated methicillin-resistant staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings |
| url | http://hdl.handle.net/20.500.11937/38180 |