Asbestos exposure and gestational trophoblastic disease: A hypothesis
Among 2,968 women and girls exposed to crocidolite (blue asbestos) at Wittenoom, three cases of choriocarcinoma and three cases of hydatidiform mole have been identified (crude incidence rate of 9.9 per 1000 women and 1.7 per 1000 deliveries for choriocarcinoma and hydatidiform mole, respectively)....
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Published: |
American Association for Cancer Research Inc
2009
|
| Online Access: | http://hdl.handle.net/20.500.11937/37961 |
| _version_ | 1848755190595846144 |
|---|---|
| author | Reid, Alison Heyworth, J. De Klerk, N. Musk, A. |
| author_facet | Reid, Alison Heyworth, J. De Klerk, N. Musk, A. |
| author_sort | Reid, Alison |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Among 2,968 women and girls exposed to crocidolite (blue asbestos) at Wittenoom, three cases of choriocarcinoma and three cases of hydatidiform mole have been identified (crude incidence rate of 9.9 per 1000 women and 1.7 per 1000 deliveries for choriocarcinoma and hydatidiform mole, respectively). The women with choriocarcinoma were resident at Wittenoom at the time of disease development, whereas hydatidiform mole occurred much later in women who had first been exposed to asbestos as young girls. Four of the six cases were known to have lived with asbestos company workers who brought their dusty work-clothes home for washing. Asbestos fibers have been reported in the lung, the pleural and peritoneal mesothelium, and the human ovary. They have also been detected in placental digests of live and stillborn infants. This cluster of gestational trophoblastic diseases has some biological plausibility for asbestos causation. Taking an occupational and residential history and examining pathologic specimens for asbestos fibers or bodies may prove useful in patients with gestational trophoblastic disease. Copyright © 2009 American Association for Cancer Research. |
| first_indexed | 2025-11-14T08:52:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-37961 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:52:22Z |
| publishDate | 2009 |
| publisher | American Association for Cancer Research Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-379612017-09-13T14:13:45Z Asbestos exposure and gestational trophoblastic disease: A hypothesis Reid, Alison Heyworth, J. De Klerk, N. Musk, A. Among 2,968 women and girls exposed to crocidolite (blue asbestos) at Wittenoom, three cases of choriocarcinoma and three cases of hydatidiform mole have been identified (crude incidence rate of 9.9 per 1000 women and 1.7 per 1000 deliveries for choriocarcinoma and hydatidiform mole, respectively). The women with choriocarcinoma were resident at Wittenoom at the time of disease development, whereas hydatidiform mole occurred much later in women who had first been exposed to asbestos as young girls. Four of the six cases were known to have lived with asbestos company workers who brought their dusty work-clothes home for washing. Asbestos fibers have been reported in the lung, the pleural and peritoneal mesothelium, and the human ovary. They have also been detected in placental digests of live and stillborn infants. This cluster of gestational trophoblastic diseases has some biological plausibility for asbestos causation. Taking an occupational and residential history and examining pathologic specimens for asbestos fibers or bodies may prove useful in patients with gestational trophoblastic disease. Copyright © 2009 American Association for Cancer Research. 2009 Journal Article http://hdl.handle.net/20.500.11937/37961 10.1158/1055-9965.EPI-09-0731 American Association for Cancer Research Inc unknown |
| spellingShingle | Reid, Alison Heyworth, J. De Klerk, N. Musk, A. Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title | Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title_full | Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title_fullStr | Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title_full_unstemmed | Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title_short | Asbestos exposure and gestational trophoblastic disease: A hypothesis |
| title_sort | asbestos exposure and gestational trophoblastic disease: a hypothesis |
| url | http://hdl.handle.net/20.500.11937/37961 |