A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy
In this paper, a novel folic acid-conjugated silica-coated titanium dioxide (TiO2–SiO2) photosensitizer was synthesized and characterized using various analytical instruments. The photosensitizer was further assessed with regards to its photoreactivity, cellular and hemocompatibility, cell internali...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/37859 |
| _version_ | 1848755163005714432 |
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| author | Feng, Xiaohui Zhang, S. Wu, H. Lou, Xia |
| author_facet | Feng, Xiaohui Zhang, S. Wu, H. Lou, Xia |
| author_sort | Feng, Xiaohui |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this paper, a novel folic acid-conjugated silica-coated titanium dioxide (TiO2–SiO2) photosensitizer was synthesized and characterized using various analytical instruments. The photosensitizer was further assessed with regards to its photoreactivity, cellular and hemocompatibility, cell internalization, and phototoxicity. Conjugating folic acid with TiO2–SiO2 has shown a significantly improved compatibility of the nanoparticles with the mouse fibroblast cells (L929) at 24 h. An improved compatibility with the human nasopharyngeal epidermoid cancer (KB) cells was also demonstrated, but to a slightly reduced degree. Enhanced cell internalization was well demonstrated in the TiO2–SiO2 folate nanoparticles. Upon exposure to UV light, TiO2–SiO2 folate nanoparticles maintained a high level photodynamic reactivity and yielded a 38–43% photo-killing of KB cells. The photo-killing effect increased with increasing dosage in the investigated concentration range of 50–100 μg ml−1. |
| first_indexed | 2025-11-14T08:51:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-37859 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:51:56Z |
| publishDate | 2015 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-378592017-09-13T15:58:42Z A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy Feng, Xiaohui Zhang, S. Wu, H. Lou, Xia Photodynamic therapy Photo-killing Titanium dioxide nanoparticles Photosensitizer Folic acid Targeting In this paper, a novel folic acid-conjugated silica-coated titanium dioxide (TiO2–SiO2) photosensitizer was synthesized and characterized using various analytical instruments. The photosensitizer was further assessed with regards to its photoreactivity, cellular and hemocompatibility, cell internalization, and phototoxicity. Conjugating folic acid with TiO2–SiO2 has shown a significantly improved compatibility of the nanoparticles with the mouse fibroblast cells (L929) at 24 h. An improved compatibility with the human nasopharyngeal epidermoid cancer (KB) cells was also demonstrated, but to a slightly reduced degree. Enhanced cell internalization was well demonstrated in the TiO2–SiO2 folate nanoparticles. Upon exposure to UV light, TiO2–SiO2 folate nanoparticles maintained a high level photodynamic reactivity and yielded a 38–43% photo-killing of KB cells. The photo-killing effect increased with increasing dosage in the investigated concentration range of 50–100 μg ml−1. 2015 Journal Article http://hdl.handle.net/20.500.11937/37859 10.1016/j.colsurfb.2014.11.035 Elsevier BV fulltext |
| spellingShingle | Photodynamic therapy Photo-killing Titanium dioxide nanoparticles Photosensitizer Folic acid Targeting Feng, Xiaohui Zhang, S. Wu, H. Lou, Xia A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title | A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title_full | A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title_fullStr | A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title_full_unstemmed | A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title_short | A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy |
| title_sort | novel folic acid-conjugated tio2–sio2 photosensitizer for cancer targeting in photodynamic therapy |
| topic | Photodynamic therapy Photo-killing Titanium dioxide nanoparticles Photosensitizer Folic acid Targeting |
| url | http://hdl.handle.net/20.500.11937/37859 |