Molecular imaging of plaques in coronary arteries with PET and SPECT
Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not...
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| Format: | Journal Article |
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Chinese P L A General Hospital * Institute of Geriatric Cardiology
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/37715 |
| _version_ | 1848755124454817792 |
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| author | Sun, Zhonghua Rashmizal, H. Xu, L. |
| author_facet | Sun, Zhonghua Rashmizal, H. Xu, L. |
| author_sort | Sun, Zhonghua |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of PET and SPECT has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed. |
| first_indexed | 2025-11-14T08:51:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-37715 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:51:19Z |
| publishDate | 2014 |
| publisher | Chinese P L A General Hospital * Institute of Geriatric Cardiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-377152017-09-13T14:28:06Z Molecular imaging of plaques in coronary arteries with PET and SPECT Sun, Zhonghua Rashmizal, H. Xu, L. single photon emission computed tomography coronary artery disease vulnerability positron emission tomography atherosclerotic plaque Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of PET and SPECT has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed. 2014 Journal Article http://hdl.handle.net/20.500.11937/37715 10.11909/j.issn.1671-5411.2014.03.005 Chinese P L A General Hospital * Institute of Geriatric Cardiology fulltext |
| spellingShingle | single photon emission computed tomography coronary artery disease vulnerability positron emission tomography atherosclerotic plaque Sun, Zhonghua Rashmizal, H. Xu, L. Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title | Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title_full | Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title_fullStr | Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title_full_unstemmed | Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title_short | Molecular imaging of plaques in coronary arteries with PET and SPECT |
| title_sort | molecular imaging of plaques in coronary arteries with pet and spect |
| topic | single photon emission computed tomography coronary artery disease vulnerability positron emission tomography atherosclerotic plaque |
| url | http://hdl.handle.net/20.500.11937/37715 |