Disparity of innate immunity-related gene effects on asthma and allergy on Karelia
Background: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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2011
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| Online Access: | http://hdl.handle.net/20.500.11937/37692 |
| _version_ | 1848755118509391872 |
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| author | Zhang, Guicheng Candelaria, P. Mäkelä, J. Khoo, S. Hayden, M. von Hertzen, L. Laatikainen, T. Vartiainen, E. Goldblatt, J. Haahtela, T. Lesouëf, N. |
| author_facet | Zhang, Guicheng Candelaria, P. Mäkelä, J. Khoo, S. Hayden, M. von Hertzen, L. Laatikainen, T. Vartiainen, E. Goldblatt, J. Haahtela, T. Lesouëf, N. |
| author_sort | Zhang, Guicheng |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. Methods: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes. Results: The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/lifestyles was significant for IL10-1082 (p=0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p=0.016) and atopy (p=0.034), IL8 781 on atopic eczema (p=0.0096), CD14 -550 on current rhinitis (p=0.022), IFNgR1 -56 on atopic eczema(p=0.038), and STAT6 2964 on current itchy rash (p=0.037) and total serum IgE (p=0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p=0.003) and Russian (p=0.01) children and overall (pooling the two populations together, p=0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. Conclusions: Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations. © 2011 John Wiley & Sons A/S. |
| first_indexed | 2025-11-14T08:51:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-37692 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:51:13Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-376922017-09-13T14:28:05Z Disparity of innate immunity-related gene effects on asthma and allergy on Karelia Zhang, Guicheng Candelaria, P. Mäkelä, J. Khoo, S. Hayden, M. von Hertzen, L. Laatikainen, T. Vartiainen, E. Goldblatt, J. Haahtela, T. Lesouëf, N. Background: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. Methods: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes. Results: The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/lifestyles was significant for IL10-1082 (p=0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p=0.016) and atopy (p=0.034), IL8 781 on atopic eczema (p=0.0096), CD14 -550 on current rhinitis (p=0.022), IFNgR1 -56 on atopic eczema(p=0.038), and STAT6 2964 on current itchy rash (p=0.037) and total serum IgE (p=0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p=0.003) and Russian (p=0.01) children and overall (pooling the two populations together, p=0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. Conclusions: Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations. © 2011 John Wiley & Sons A/S. 2011 Journal Article http://hdl.handle.net/20.500.11937/37692 10.1111/j.1399-3038.2011.01186.x restricted |
| spellingShingle | Zhang, Guicheng Candelaria, P. Mäkelä, J. Khoo, S. Hayden, M. von Hertzen, L. Laatikainen, T. Vartiainen, E. Goldblatt, J. Haahtela, T. Lesouëf, N. Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title | Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title_full | Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title_fullStr | Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title_full_unstemmed | Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title_short | Disparity of innate immunity-related gene effects on asthma and allergy on Karelia |
| title_sort | disparity of innate immunity-related gene effects on asthma and allergy on karelia |
| url | http://hdl.handle.net/20.500.11937/37692 |