Detection of liver injury in IBD using Transient Elastography
Background: Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies. Aims: Our aim was to evaluate the...
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| Format: | Journal Article |
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Elsevier BV
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/37600 |
| _version_ | 1848755094039822336 |
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| author | Thin, L. Lawrance, I. Spilsbury, Katrina Kava, J. Olynyk, John |
| author_facet | Thin, L. Lawrance, I. Spilsbury, Katrina Kava, J. Olynyk, John |
| author_sort | Thin, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies. Aims: Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥ 8 kPa using transient elastography (TE). Methods: 110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE. Results: 71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P = 0.013). Seven IBD patients (6.4%) had an LS over 8 kPa and 3 had persistently elevated LS 6 months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with higher LS in the IBD but not in the control group (P < 0.001 and 0.010 respectively). Conclusion: Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients. |
| first_indexed | 2025-11-14T08:50:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-37600 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:50:50Z |
| publishDate | 2014 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-376002019-02-19T05:35:07Z Detection of liver injury in IBD using Transient Elastography Thin, L. Lawrance, I. Spilsbury, Katrina Kava, J. Olynyk, John NAFLD Liver stiffness IBD Transient elastography Background: Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies. Aims: Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥ 8 kPa using transient elastography (TE). Methods: 110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE. Results: 71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P = 0.013). Seven IBD patients (6.4%) had an LS over 8 kPa and 3 had persistently elevated LS 6 months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with higher LS in the IBD but not in the control group (P < 0.001 and 0.010 respectively). Conclusion: Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients. 2014 Journal Article http://hdl.handle.net/20.500.11937/37600 10.1016/j.crohns.2013.12.006 Elsevier BV fulltext |
| spellingShingle | NAFLD Liver stiffness IBD Transient elastography Thin, L. Lawrance, I. Spilsbury, Katrina Kava, J. Olynyk, John Detection of liver injury in IBD using Transient Elastography |
| title | Detection of liver injury in IBD using Transient Elastography |
| title_full | Detection of liver injury in IBD using Transient Elastography |
| title_fullStr | Detection of liver injury in IBD using Transient Elastography |
| title_full_unstemmed | Detection of liver injury in IBD using Transient Elastography |
| title_short | Detection of liver injury in IBD using Transient Elastography |
| title_sort | detection of liver injury in ibd using transient elastography |
| topic | NAFLD Liver stiffness IBD Transient elastography |
| url | http://hdl.handle.net/20.500.11937/37600 |