In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk
Objectives. To examine the risk of invasive epithelial ovarian cancer in a cohort of women seeking treatment for infertility. Methods. Using whole-population linked hospital and registry data, we conducted a cohort study of21,646 women commencing hospital investigation and treatment for infertility...
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| Format: | Journal Article |
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Elsevier Inc
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/37552 |
| _version_ | 1848755080438743040 |
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| author | Stewart, L. Holman, C D. Aboagye-Sarfo, P. Finn, Judith Preen, D. Hart, R. |
| author_facet | Stewart, L. Holman, C D. Aboagye-Sarfo, P. Finn, Judith Preen, D. Hart, R. |
| author_sort | Stewart, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives. To examine the risk of invasive epithelial ovarian cancer in a cohort of women seeking treatment for infertility. Methods. Using whole-population linked hospital and registry data, we conducted a cohort study of21,646 women commencing hospital investigation and treatment for infertility in Western Australia in the years 1982–2002.We examined the effects of IVF treatment, endometriosis and parity on risk of ovarian cancer and explored potential confounding by tubal ligation, hysterectomy and unilateral oophorectomy/ salpingo-oophorectomy (USO). Results. Parous women undergoing IVF had no observable increase in the rate of ovarian cancer (hazard ratio [HR] 1.01; 95% confidence interval [CI] 0.35–2.90); the HR in women who had IVF and remained nulliparous was 1.76 (95% CI 0.74–4.16). Women diagnosed with endometriosis who remained nulliparous had a three-fold increase in the rate of ovarian cancer (HR 3.11; 95% CI 1.13–8.57); the HR in parous women was 1.52 (95% CI 0.34– 6.75). In separate analyses, women who had a USO without hysterectomy had a four-fold increase in the rate of ovarian cancer (HR 4.23; 95% CI 1.30–13.77). Hysterectomy with or without USO appeared protective. Conclusions. There is no evidence of an increased risk of ovarian cancer following IVF in women who give birth. There is some uncertainty regarding the effect of IVF in women who remain nulliparous. Parous women diagnosed with endometriosis may have a slightly increased risk of ovarian cancer; nulliparous women have a marked increase in risk. |
| first_indexed | 2025-11-14T08:50:37Z |
| format | Journal Article |
| id | curtin-20.500.11937-37552 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:50:37Z |
| publishDate | 2013 |
| publisher | Elsevier Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-375522017-09-13T13:42:27Z In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk Stewart, L. Holman, C D. Aboagye-Sarfo, P. Finn, Judith Preen, D. Hart, R. Ovarian cancer Hazard ratios Risk factors In vitro fertilization Cohort study Objectives. To examine the risk of invasive epithelial ovarian cancer in a cohort of women seeking treatment for infertility. Methods. Using whole-population linked hospital and registry data, we conducted a cohort study of21,646 women commencing hospital investigation and treatment for infertility in Western Australia in the years 1982–2002.We examined the effects of IVF treatment, endometriosis and parity on risk of ovarian cancer and explored potential confounding by tubal ligation, hysterectomy and unilateral oophorectomy/ salpingo-oophorectomy (USO). Results. Parous women undergoing IVF had no observable increase in the rate of ovarian cancer (hazard ratio [HR] 1.01; 95% confidence interval [CI] 0.35–2.90); the HR in women who had IVF and remained nulliparous was 1.76 (95% CI 0.74–4.16). Women diagnosed with endometriosis who remained nulliparous had a three-fold increase in the rate of ovarian cancer (HR 3.11; 95% CI 1.13–8.57); the HR in parous women was 1.52 (95% CI 0.34– 6.75). In separate analyses, women who had a USO without hysterectomy had a four-fold increase in the rate of ovarian cancer (HR 4.23; 95% CI 1.30–13.77). Hysterectomy with or without USO appeared protective. Conclusions. There is no evidence of an increased risk of ovarian cancer following IVF in women who give birth. There is some uncertainty regarding the effect of IVF in women who remain nulliparous. Parous women diagnosed with endometriosis may have a slightly increased risk of ovarian cancer; nulliparous women have a marked increase in risk. 2013 Journal Article http://hdl.handle.net/20.500.11937/37552 10.1016/j.ygyno.2012.10.023 Elsevier Inc restricted |
| spellingShingle | Ovarian cancer Hazard ratios Risk factors In vitro fertilization Cohort study Stewart, L. Holman, C D. Aboagye-Sarfo, P. Finn, Judith Preen, D. Hart, R. In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title | In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title_full | In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title_fullStr | In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title_full_unstemmed | In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title_short | In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| title_sort | in vitro fertilization, endometriosis, nulliparity and ovarian cancer risk |
| topic | Ovarian cancer Hazard ratios Risk factors In vitro fertilization Cohort study |
| url | http://hdl.handle.net/20.500.11937/37552 |