Cytomegalovirus antibody and vascular pathology in renal transplant recipients
Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients t...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
WILEY-LISS
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/37480 |
| _version_ | 1848755060076445696 |
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| author | Price, Patricia Lee, Silvia Affandi, Jacquita Parsons, Richard Naylor, L. Watts, G. Irish, A. |
| author_facet | Price, Patricia Lee, Silvia Affandi, Jacquita Parsons, Richard Naylor, L. Watts, G. Irish, A. |
| author_sort | Price, Patricia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. |
| first_indexed | 2025-11-14T08:50:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-37480 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:50:18Z |
| publishDate | 2017 |
| publisher | WILEY-LISS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-374802017-11-03T01:31:18Z Cytomegalovirus antibody and vascular pathology in renal transplant recipients Price, Patricia Lee, Silvia Affandi, Jacquita Parsons, Richard Naylor, L. Watts, G. Irish, A. Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. 2017 Journal Article http://hdl.handle.net/20.500.11937/37480 10.1002/jmv.24602 WILEY-LISS fulltext |
| spellingShingle | Price, Patricia Lee, Silvia Affandi, Jacquita Parsons, Richard Naylor, L. Watts, G. Irish, A. Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title | Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title_full | Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title_fullStr | Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title_full_unstemmed | Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title_short | Cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| title_sort | cytomegalovirus antibody and vascular pathology in renal transplant recipients |
| url | http://hdl.handle.net/20.500.11937/37480 |