IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease
Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patien...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
Lippincott Williams and Wilkins
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/37406 |
| _version_ | 1848755038330028032 |
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| author | Price, Patricia James, I. |
| author_facet | Price, Patricia James, I. |
| author_sort | Price, Patricia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patients with CD4 T-cell count of =100 cells/µl at baseline, IL1A+4845TT was associated with poor virological outcome (P = 0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845T did not affect outcome. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| first_indexed | 2025-11-14T08:49:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-37406 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:49:57Z |
| publishDate | 2009 |
| publisher | Lippincott Williams and Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-374062017-09-13T13:38:14Z IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease Price, Patricia James, I. Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patients with CD4 T-cell count of =100 cells/µl at baseline, IL1A+4845TT was associated with poor virological outcome (P = 0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845T did not affect outcome. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. 2009 Journal Article http://hdl.handle.net/20.500.11937/37406 10.1097/QAD.0b013e32832c4118 Lippincott Williams and Wilkins unknown |
| spellingShingle | Price, Patricia James, I. IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title | IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title_full | IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title_fullStr | IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title_full_unstemmed | IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title_short | IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease |
| title_sort | il1a alleles associate with a virological response to antiretroviral therapy in hiv patients beginning therapy with advanced disease |
| url | http://hdl.handle.net/20.500.11937/37406 |