IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease
Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patien...
| Main Authors: | , |
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| Format: | Journal Article |
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Lippincott Williams and Wilkins
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/37406 |
| Summary: | Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patients with CD4 T-cell count of =100 cells/µl at baseline, IL1A+4845TT was associated with poor virological outcome (P = 0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845T did not affect outcome. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
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