Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.

Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.

We recently reported a novel interaction between Bcl-2 and Rac1 and linked that to the ability of Bcl-2 to induce a pro-oxidant state in cancer cells. To gain further insight into the functional relevance of this interaction, we utilized computer simulation based on the protein pathway dynamic netwo...

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Bibliographic Details
Main Authors: Kang, J., Chong, S., Ooi, V., Vali, S., Kumar, A., Kapoor, S., Abbasi, T., Hirpara, J., Loh, T., Goh, B., Pervaiz, Shazib
Format: Journal Article
Published: 2015
Online Access:http://hdl.handle.net/20.500.11937/37356

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