Spinal projections from the presumptive midbrain locomotor region in the mouse
The mesencephalic locomotor region (MLR) plays an important role in the control of locomotion, but there is ongoing debate about the anatomy of its connections with the spinal cord. In this study, we have examined the spinal projections of the mouse precuneiform nucleus (PrCnF), which lies within th...
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| Format: | Journal Article |
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Springer
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/37015 |
| _version_ | 1848754930702090240 |
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| author | Liang, H. Paxinos, G. Watson, Charles |
| author_facet | Liang, H. Paxinos, G. Watson, Charles |
| author_sort | Liang, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The mesencephalic locomotor region (MLR) plays an important role in the control of locomotion, but there is ongoing debate about the anatomy of its connections with the spinal cord. In this study, we have examined the spinal projections of the mouse precuneiform nucleus (PrCnF), which lies within the boundaries of the presumptive MLR. We used both retrograde and anterograde labeling techniques. Small clusters of labeled neurons were seen in the medial portion of the PrCnF following fluorogold injections in the upper cervical spinal cord. Fewer labeled neurons were seen in the PrCnF after upper thoracic injections. Following the injection of anterograde tracer (biotinylated dextran amine) into the PrCnF, labelled fibers were clearly observed in the spinal cord. These fibers travelled in the ventral and lateral funiculi, and terminated mainly in the medial portions of laminae 7, 8, and 9, as well as area 10, with an ipsilateral predominance. Our observations indicate that projections from the PrCnF to the spinal cord may provide an anatomical substrate for the role of the MLR in locomotion. |
| first_indexed | 2025-11-14T08:48:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-37015 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:48:14Z |
| publishDate | 2012 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-370152017-09-13T15:16:05Z Spinal projections from the presumptive midbrain locomotor region in the mouse Liang, H. Paxinos, G. Watson, Charles Fluoro-gold Biotinylated dextran amine Spinal cord Precuneiform nucleus The mesencephalic locomotor region (MLR) plays an important role in the control of locomotion, but there is ongoing debate about the anatomy of its connections with the spinal cord. In this study, we have examined the spinal projections of the mouse precuneiform nucleus (PrCnF), which lies within the boundaries of the presumptive MLR. We used both retrograde and anterograde labeling techniques. Small clusters of labeled neurons were seen in the medial portion of the PrCnF following fluorogold injections in the upper cervical spinal cord. Fewer labeled neurons were seen in the PrCnF after upper thoracic injections. Following the injection of anterograde tracer (biotinylated dextran amine) into the PrCnF, labelled fibers were clearly observed in the spinal cord. These fibers travelled in the ventral and lateral funiculi, and terminated mainly in the medial portions of laminae 7, 8, and 9, as well as area 10, with an ipsilateral predominance. Our observations indicate that projections from the PrCnF to the spinal cord may provide an anatomical substrate for the role of the MLR in locomotion. 2012 Journal Article http://hdl.handle.net/20.500.11937/37015 10.1007/s00429-011-0337-6 Springer restricted |
| spellingShingle | Fluoro-gold Biotinylated dextran amine Spinal cord Precuneiform nucleus Liang, H. Paxinos, G. Watson, Charles Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title | Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title_full | Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title_fullStr | Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title_full_unstemmed | Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title_short | Spinal projections from the presumptive midbrain locomotor region in the mouse |
| title_sort | spinal projections from the presumptive midbrain locomotor region in the mouse |
| topic | Fluoro-gold Biotinylated dextran amine Spinal cord Precuneiform nucleus |
| url | http://hdl.handle.net/20.500.11937/37015 |