Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation
Background: Partial thickness skin graft wounds are painful. Topically applied lidocaine has been used for analgesia in several clinical trials. This study compared the effectiveness of two different formulations of topical local anaesthetic for dressing changes of partial thickness skin graft dono...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Pergamon
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/36859 |
| _version_ | 1848754887899217920 |
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| author | Desai, Chirag Wood, F. Schug, S. Parsons, Richard Fridlender, C. Sunderland, Vivian Bruce |
| author_facet | Desai, Chirag Wood, F. Schug, S. Parsons, Richard Fridlender, C. Sunderland, Vivian Bruce |
| author_sort | Desai, Chirag |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Partial thickness skin graft wounds are painful. Topically applied lidocaine has been used for analgesia in several clinical trials. This study compared the effectiveness of two different formulations of topical local anaesthetic for dressing changes of partial thickness skin graft donor sites.Methods: A double-blind randomised controlled, pilot trial was conducted in 29 patients undergoing split thickness skin graft surgery. Subjects were randomised to either a 3% lidocaine emulsion formulation ‘‘Treatment E’’ (NOPAYNETM) or a 4% aqueous solution ‘‘Treatment A’’ (XylocaineTM). Subjects received one spray per 3 cm2 of donor site area followed by up to two further spays as required. Endpoints included pain intensity measured by the numerical rating scale (NRS) up to 1 h after dressing change commencement, sting sensation, overall satisfaction and lidocaine plasma concentration.Results: The 60 min pain scores for E and A were 1.3 ±0.3 (mean ±SEM) and 1.8 ±0.4 (ƿ = 0.98) respectively. Nearly 90% of patients were very satisfied with their treatment. The mean plasma concentrations of lidocaine for A and E were 0.132 mg/l and 0.040 mg/l respectively (ƿ = 0.069).Conclusion: The topical local anaesthetic formulations achieved low pain scores during dressing changes. The safety profile was potentially improved with the emulsion formulation of lidocaine. |
| first_indexed | 2025-11-14T08:47:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-36859 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:47:33Z |
| publishDate | 2014 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-368592017-09-13T15:22:17Z Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation Desai, Chirag Wood, F. Schug, S. Parsons, Richard Fridlender, C. Sunderland, Vivian Bruce Burns Lidocaine spray Emulsion Partial thickness skin graft Local anaesthetic formulation Lidocaine Skin graft wound Donor site dressing change Burn pain Background: Partial thickness skin graft wounds are painful. Topically applied lidocaine has been used for analgesia in several clinical trials. This study compared the effectiveness of two different formulations of topical local anaesthetic for dressing changes of partial thickness skin graft donor sites.Methods: A double-blind randomised controlled, pilot trial was conducted in 29 patients undergoing split thickness skin graft surgery. Subjects were randomised to either a 3% lidocaine emulsion formulation ‘‘Treatment E’’ (NOPAYNETM) or a 4% aqueous solution ‘‘Treatment A’’ (XylocaineTM). Subjects received one spray per 3 cm2 of donor site area followed by up to two further spays as required. Endpoints included pain intensity measured by the numerical rating scale (NRS) up to 1 h after dressing change commencement, sting sensation, overall satisfaction and lidocaine plasma concentration.Results: The 60 min pain scores for E and A were 1.3 ±0.3 (mean ±SEM) and 1.8 ±0.4 (ƿ = 0.98) respectively. Nearly 90% of patients were very satisfied with their treatment. The mean plasma concentrations of lidocaine for A and E were 0.132 mg/l and 0.040 mg/l respectively (ƿ = 0.069).Conclusion: The topical local anaesthetic formulations achieved low pain scores during dressing changes. The safety profile was potentially improved with the emulsion formulation of lidocaine. 2014 Journal Article http://hdl.handle.net/20.500.11937/36859 10.1016/j.burns.2013.05.013 Pergamon restricted |
| spellingShingle | Burns Lidocaine spray Emulsion Partial thickness skin graft Local anaesthetic formulation Lidocaine Skin graft wound Donor site dressing change Burn pain Desai, Chirag Wood, F. Schug, S. Parsons, Richard Fridlender, C. Sunderland, Vivian Bruce Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title | Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title_full | Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title_fullStr | Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title_full_unstemmed | Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title_short | Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| title_sort | effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: a double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation |
| topic | Burns Lidocaine spray Emulsion Partial thickness skin graft Local anaesthetic formulation Lidocaine Skin graft wound Donor site dressing change Burn pain |
| url | http://hdl.handle.net/20.500.11937/36859 |