The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUN...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/36138 |
| _version_ | 1848754686246518784 |
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| author | Soong, R. Shah, N. Peh, B. Chong, P. Ng, S. Zeps, Nikolajs Joseph, D. Salto-Tellez, M. Iacopetta, B. Ito, Y. |
| author_facet | Soong, R. Shah, N. Peh, B. Chong, P. Ng, S. Zeps, Nikolajs Joseph, D. Salto-Tellez, M. Iacopetta, B. Ito, Y. |
| author_sort | Soong, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUNX3 expression in a large series of colorectal cancers using immunohistochemistry and tissue arrays. With advancing tumour stage, expression of RUNX3 in the nucleus decreased, whereas expression restricted to the cytoplasmic compartment increased. Nuclear RUNX3 expression was associated with significantly better patient survival compared to tumours in which the expression of RUNX3 was restricted to the cytoplasm (P=0.025). These results support a role for RUNX3 as a tumour suppressor in colorectal cancer. © 2009 Cancer Research UK. |
| first_indexed | 2025-11-14T08:44:21Z |
| format | Journal Article |
| id | curtin-20.500.11937-36138 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:44:21Z |
| publishDate | 2009 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-361382017-09-13T15:18:39Z The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome Soong, R. Shah, N. Peh, B. Chong, P. Ng, S. Zeps, Nikolajs Joseph, D. Salto-Tellez, M. Iacopetta, B. Ito, Y. RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUNX3 expression in a large series of colorectal cancers using immunohistochemistry and tissue arrays. With advancing tumour stage, expression of RUNX3 in the nucleus decreased, whereas expression restricted to the cytoplasmic compartment increased. Nuclear RUNX3 expression was associated with significantly better patient survival compared to tumours in which the expression of RUNX3 was restricted to the cytoplasm (P=0.025). These results support a role for RUNX3 as a tumour suppressor in colorectal cancer. © 2009 Cancer Research UK. 2009 Journal Article http://hdl.handle.net/20.500.11937/36138 10.1038/sj.bjc.6604899 Nature Publishing Group unknown |
| spellingShingle | Soong, R. Shah, N. Peh, B. Chong, P. Ng, S. Zeps, Nikolajs Joseph, D. Salto-Tellez, M. Iacopetta, B. Ito, Y. The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title_full | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title_fullStr | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title_full_unstemmed | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title_short | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome |
| title_sort | expression of runx3 in colorectal cancer is associated with disease stage and patient outcome |
| url | http://hdl.handle.net/20.500.11937/36138 |