Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development
There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the devel...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2009
|
| Online Access: | http://hdl.handle.net/20.500.11937/36105 |
| _version_ | 1848754676909998080 |
|---|---|
| author | Akkari, Patrick Swanson, T. Crenshaw, D. Grossman, I. Sundseth, S. Burns, D. Roses, A. |
| author_facet | Akkari, Patrick Swanson, T. Crenshaw, D. Grossman, I. Sundseth, S. Burns, D. Roses, A. |
| author_sort | Akkari, Patrick |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the development of new stratified drugs. We describe here the concept of pipeline pharmacogenetics and its application throughout the phases of drug discovery. Pipeline pharmacogenetics enables the evaluation of the genetic contribution to safety potentially lowering barriers to registration as well as providing rationale for efficacy and enabling co-development of genetic in vitro diagnostics. © 2009 Bentham Science Publishers Ltd. |
| first_indexed | 2025-11-14T08:44:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-36105 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:44:12Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-361052017-09-13T15:17:40Z Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development Akkari, Patrick Swanson, T. Crenshaw, D. Grossman, I. Sundseth, S. Burns, D. Roses, A. There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the development of new stratified drugs. We describe here the concept of pipeline pharmacogenetics and its application throughout the phases of drug discovery. Pipeline pharmacogenetics enables the evaluation of the genetic contribution to safety potentially lowering barriers to registration as well as providing rationale for efficacy and enabling co-development of genetic in vitro diagnostics. © 2009 Bentham Science Publishers Ltd. 2009 Journal Article http://hdl.handle.net/20.500.11937/36105 10.2174/138161209789649538 restricted |
| spellingShingle | Akkari, Patrick Swanson, T. Crenshaw, D. Grossman, I. Sundseth, S. Burns, D. Roses, A. Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title | Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title_full | Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title_fullStr | Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title_full_unstemmed | Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title_short | Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development |
| title_sort | pipeline pharmacogenetics: a novel approach to integrating pharmacogenetics into drug development |
| url | http://hdl.handle.net/20.500.11937/36105 |