Primary haemostasis: Newer insights
At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, t...
| Main Authors: | , , |
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| Format: | Journal Article |
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Blackwell Publishing Ltd
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/36093 |
| _version_ | 1848754673825087488 |
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| author | Berndt, Michael Metharom, Pat Andrews, R. |
| author_facet | Berndt, Michael Metharom, Pat Andrews, R. |
| author_sort | Berndt, Michael |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, these studies are redefining the intricate networks linking haemostasis and thrombosis with inflammation, infectious disease, cancer/metastasis and other vascular pathophysiology. The focus of this state-of-the-art review is some of the newer advances relevant to primary haemostasis. Of particular interest, platelet-specific primary adhesion-signalling receptors and associated activation pathways control platelet function in flowing blood and provide molecular links to other systems. Platelet glycoprotein (GP)Iba of the GPIb-IX-V complex and GPVI not only initiate platelet aggregation and thrombus formation by primary interactions with von Willebrand factor and collagen, respectively, but are also involved in coagulation, leucocyte engagement, bacterial or viral interactions, and are relevant as potential risk markers in a range of human diseases. Understanding these systems in unprecedented detail promises significant advances in evaluation of individual risk, in new diagnostic or therapeutic possibilities and in monitoring the response to drugs or other treatment. © 2014 John Wiley & Sons Ltd. |
| first_indexed | 2025-11-14T08:44:09Z |
| format | Journal Article |
| id | curtin-20.500.11937-36093 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:44:09Z |
| publishDate | 2014 |
| publisher | Blackwell Publishing Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-360932017-09-13T15:18:09Z Primary haemostasis: Newer insights Berndt, Michael Metharom, Pat Andrews, R. At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, these studies are redefining the intricate networks linking haemostasis and thrombosis with inflammation, infectious disease, cancer/metastasis and other vascular pathophysiology. The focus of this state-of-the-art review is some of the newer advances relevant to primary haemostasis. Of particular interest, platelet-specific primary adhesion-signalling receptors and associated activation pathways control platelet function in flowing blood and provide molecular links to other systems. Platelet glycoprotein (GP)Iba of the GPIb-IX-V complex and GPVI not only initiate platelet aggregation and thrombus formation by primary interactions with von Willebrand factor and collagen, respectively, but are also involved in coagulation, leucocyte engagement, bacterial or viral interactions, and are relevant as potential risk markers in a range of human diseases. Understanding these systems in unprecedented detail promises significant advances in evaluation of individual risk, in new diagnostic or therapeutic possibilities and in monitoring the response to drugs or other treatment. © 2014 John Wiley & Sons Ltd. 2014 Journal Article http://hdl.handle.net/20.500.11937/36093 10.1111/hae.12427 Blackwell Publishing Ltd unknown |
| spellingShingle | Berndt, Michael Metharom, Pat Andrews, R. Primary haemostasis: Newer insights |
| title | Primary haemostasis: Newer insights |
| title_full | Primary haemostasis: Newer insights |
| title_fullStr | Primary haemostasis: Newer insights |
| title_full_unstemmed | Primary haemostasis: Newer insights |
| title_short | Primary haemostasis: Newer insights |
| title_sort | primary haemostasis: newer insights |
| url | http://hdl.handle.net/20.500.11937/36093 |