Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults
Background - There is increasing evidence supporting an association of higher serum vitamin D concentration with better cognitive performance in older individuals. However, to date, consideration of the putative association between vitamin D and cognition has been based principally on studies invest...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Springer Medizin
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/35976 |
| _version_ | 1848754641744953344 |
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| author | Lam, Virginie Albrecht, Matthew Takechi, Ryu Prasopsang, P. Lee, Ya Ping Foster, Jonathan Mamo, John |
| author_facet | Lam, Virginie Albrecht, Matthew Takechi, Ryu Prasopsang, P. Lee, Ya Ping Foster, Jonathan Mamo, John |
| author_sort | Lam, Virginie |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background - There is increasing evidence supporting an association of higher serum vitamin D concentration with better cognitive performance in older individuals. However, to date, consideration of the putative association between vitamin D and cognition has been based principally on studies investigating clinical participant samples manifesting vitamin D deficiency, particularly in older people. Moreover, relationships between vitamin D and cognition are typically not considered in the context of counter-regulatory calcium-modulating hormones or calcium homeostasis. Objective - Serum vitamin D/bioactive (ionised) calcium/parathyroid hormone homeostasis was considered in the context of cognitive performance in healthy, middle-aged and older individuals. Design - A cross-sectional sample of 179 participants between the ages of 47–84 years was recruited for this study (114 females, 65 males). Participants provided fasting blood samples for analysis of serum 25-hydroxyvitamin D levels, ionised calcium (iCa) and parathyroid hormone (PTH) and completed cognitive measures of verbal episodic learning and memory. Results - Serum 25-hydroxyvitamin D concentrations were negatively associated (with and without covariates of age, gender, depression and NART scores, iCa, and PTH) with measures of verbal episodic learning and memory, in particular with trial 5 of the Rey Auditory Verbal Learning Test (RAVLT) and long-delay free recall on the RAVLT. Conclusion - Overall, the findings from this study suggest an association between higher vitamin D status and poorer performance on verbal episodic memory in middle-aged and older individuals with normal vitamin D–calcium–PTH homeostasis. Despite requiring replication in other participant samples, this is a potentially important finding as it indicates that it may not be beneficial from a cognitive perspective to provide vitamin D supplements in individuals with already adequate vitamin D status. |
| first_indexed | 2025-11-14T08:43:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-35976 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:43:39Z |
| publishDate | 2015 |
| publisher | Springer Medizin |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-359762017-09-13T15:15:33Z Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults Lam, Virginie Albrecht, Matthew Takechi, Ryu Prasopsang, P. Lee, Ya Ping Foster, Jonathan Mamo, John Serum 25-hydroxyvitamin D Vitamin D Verbal episodic memory Parathyroid hormone Ionised calcium Cognition Background - There is increasing evidence supporting an association of higher serum vitamin D concentration with better cognitive performance in older individuals. However, to date, consideration of the putative association between vitamin D and cognition has been based principally on studies investigating clinical participant samples manifesting vitamin D deficiency, particularly in older people. Moreover, relationships between vitamin D and cognition are typically not considered in the context of counter-regulatory calcium-modulating hormones or calcium homeostasis. Objective - Serum vitamin D/bioactive (ionised) calcium/parathyroid hormone homeostasis was considered in the context of cognitive performance in healthy, middle-aged and older individuals. Design - A cross-sectional sample of 179 participants between the ages of 47–84 years was recruited for this study (114 females, 65 males). Participants provided fasting blood samples for analysis of serum 25-hydroxyvitamin D levels, ionised calcium (iCa) and parathyroid hormone (PTH) and completed cognitive measures of verbal episodic learning and memory. Results - Serum 25-hydroxyvitamin D concentrations were negatively associated (with and without covariates of age, gender, depression and NART scores, iCa, and PTH) with measures of verbal episodic learning and memory, in particular with trial 5 of the Rey Auditory Verbal Learning Test (RAVLT) and long-delay free recall on the RAVLT. Conclusion - Overall, the findings from this study suggest an association between higher vitamin D status and poorer performance on verbal episodic memory in middle-aged and older individuals with normal vitamin D–calcium–PTH homeostasis. Despite requiring replication in other participant samples, this is a potentially important finding as it indicates that it may not be beneficial from a cognitive perspective to provide vitamin D supplements in individuals with already adequate vitamin D status. 2015 Journal Article http://hdl.handle.net/20.500.11937/35976 10.1007/s00394-015-0968-0 Springer Medizin restricted |
| spellingShingle | Serum 25-hydroxyvitamin D Vitamin D Verbal episodic memory Parathyroid hormone Ionised calcium Cognition Lam, Virginie Albrecht, Matthew Takechi, Ryu Prasopsang, P. Lee, Ya Ping Foster, Jonathan Mamo, John Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title | Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title_full | Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title_fullStr | Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title_full_unstemmed | Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title_short | Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| title_sort | serum 25-hydroxyvitamin d is associated with reduced verbal episodic memory in healthy, middle-aged and older adults |
| topic | Serum 25-hydroxyvitamin D Vitamin D Verbal episodic memory Parathyroid hormone Ionised calcium Cognition |
| url | http://hdl.handle.net/20.500.11937/35976 |