Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study
We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The "pain-protective" 3-SNP haplotype and a 6-SNP haplotype containing t...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/35713 |
| _version_ | 1848754570520428544 |
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| author | Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. |
| author_facet | Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. |
| author_sort | Wadley, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The "pain-protective" 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender, and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently, the role of GTP cyclohydrolase 1 in painful HIV-associated sensory neuropathy remains possible. Copyright © 2012 by Lippincott Williams & Wilkins. |
| first_indexed | 2025-11-14T08:42:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-35713 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:42:31Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-357132017-09-13T15:30:50Z Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The "pain-protective" 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender, and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently, the role of GTP cyclohydrolase 1 in painful HIV-associated sensory neuropathy remains possible. Copyright © 2012 by Lippincott Williams & Wilkins. 2012 Journal Article http://hdl.handle.net/20.500.11937/35713 10.1097/QAI.0b013e31824bcc17 unknown |
| spellingShingle | Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title | Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title_full | Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title_fullStr | Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title_full_unstemmed | Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title_short | Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study |
| title_sort | analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the gch1 gene in africans with hiv-associated sensory neuropathy: a genetic association study |
| url | http://hdl.handle.net/20.500.11937/35713 |