Folding Pathways for Initiator and Effector Procaspases from Computer Simulations

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Folding Pathways for Initiator and Effector Procaspases from Computer Simulations

The folding pathways of procaspases 3, 7, and 8 have been studied using a Go-like Hamiltonian and molecular dynamics simulations coupled with a parallel tempering scheme. The folding pathways and the overall structures of procaspases 3 and 7 are similar, and are characterized by monomeric as well as...

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Bibliographic Details
Main Authors:	Piana, Stefano, Taylor, Zoe, Rothlisberger, U.
Format:	Journal Article
Published:	Wiley-Liss 2005
Subjects:	Fas-mediated apoptosis molecular dynamics simulations procaspase 3 procaspase 7 procaspase 8 folding
Online Access:	http://hdl.handle.net/20.500.11937/35535

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