Non-canonical peptides bound to MHC
Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular pepti...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/35489 |
| _version_ | 1848754510857502720 |
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| author | Day, S. Ramsland, Paul Apostolopoulos, V. |
| author_facet | Day, S. Ramsland, Paul Apostolopoulos, V. |
| author_sort | Day, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies. © 2009 Bentham Science Publishers Ltd. |
| first_indexed | 2025-11-14T08:41:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-35489 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:41:34Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-354892017-09-13T15:26:00Z Non-canonical peptides bound to MHC Day, S. Ramsland, Paul Apostolopoulos, V. Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies. © 2009 Bentham Science Publishers Ltd. 2009 Journal Article http://hdl.handle.net/20.500.11937/35489 10.2174/138161209789105090 restricted |
| spellingShingle | Day, S. Ramsland, Paul Apostolopoulos, V. Non-canonical peptides bound to MHC |
| title | Non-canonical peptides bound to MHC |
| title_full | Non-canonical peptides bound to MHC |
| title_fullStr | Non-canonical peptides bound to MHC |
| title_full_unstemmed | Non-canonical peptides bound to MHC |
| title_short | Non-canonical peptides bound to MHC |
| title_sort | non-canonical peptides bound to mhc |
| url | http://hdl.handle.net/20.500.11937/35489 |