Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging
An increase in reactive oxygen species (ROS) and a decrease in endogenous antioxidant defense mechanisms are observed in both aging and diabetes. The mechanisms driving an increase in ROS are generally associated with low-grade inflammation in obesity, diabetes and aging. The sources of ROS, sources...
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| Format: | Book Chapter |
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Springer Verlag
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/35273 |
| _version_ | 1848754451942211584 |
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| author | Newsholme, Philip Krause, M. |
| author2 | Ismail Laher |
| author_facet | Ismail Laher Newsholme, Philip Krause, M. |
| author_sort | Newsholme, Philip |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | An increase in reactive oxygen species (ROS) and a decrease in endogenous antioxidant defense mechanisms are observed in both aging and diabetes. The mechanisms driving an increase in ROS are generally associated with low-grade inflammation in obesity, diabetes and aging. The sources of ROS, sources of antioxidants, and the impact on mitochondrial function are described in this chapter and the relevance of imbalances in favor of ROS generation to loss of muscle function in both aging and diabetes are described in more detail. |
| first_indexed | 2025-11-14T08:40:38Z |
| format | Book Chapter |
| id | curtin-20.500.11937-35273 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:40:38Z |
| publishDate | 2014 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-352732017-09-13T15:20:56Z Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging Newsholme, Philip Krause, M. Ismail Laher Reactive nitrogen species Reactive oxygen species Oxidative stress Diet and exercise intervention An increase in reactive oxygen species (ROS) and a decrease in endogenous antioxidant defense mechanisms are observed in both aging and diabetes. The mechanisms driving an increase in ROS are generally associated with low-grade inflammation in obesity, diabetes and aging. The sources of ROS, sources of antioxidants, and the impact on mitochondrial function are described in this chapter and the relevance of imbalances in favor of ROS generation to loss of muscle function in both aging and diabetes are described in more detail. 2014 Book Chapter http://hdl.handle.net/20.500.11937/35273 10.1007/978-3-642-30018-9_152 Springer Verlag restricted |
| spellingShingle | Reactive nitrogen species Reactive oxygen species Oxidative stress Diet and exercise intervention Newsholme, Philip Krause, M. Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title | Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title_full | Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title_fullStr | Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title_full_unstemmed | Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title_short | Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging |
| title_sort | diet, obesity, and reactive oxygen species – implications for diabetes and aging |
| topic | Reactive nitrogen species Reactive oxygen species Oxidative stress Diet and exercise intervention |
| url | http://hdl.handle.net/20.500.11937/35273 |