Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice
Molecular mechanisms that are associated with age-related denervation and loss of skeletal muscle mass and function (sarcopenia) are described for female C57Bl/6J mice aged 3, 15, 24, 27 and 29 months (m). Changes in mRNAs and proteins associated with myofibre denervation and protein metabolism in a...
| Main Authors: | Barns, M., Gondro, C., Tellam, R., Crabb, Hannah, Grounds, M., Shavlakadze, T. |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/3511 |
Similar Items
Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice
by: McMahon, C., et al.
Published: (2014)
by: McMahon, C., et al.
Published: (2014)
Investigating a novel exercise training strategy on neuromuscular health
by: Ely, Isabel A
Published: (2020)
by: Ely, Isabel A
Published: (2020)
Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function
by: Smart, Thomas
Published: (2024)
by: Smart, Thomas
Published: (2024)
The impact of leucine-enriched whey protein on skeletal muscle anabolism
by: Ely, Isabel
Published: (2024)
by: Ely, Isabel
Published: (2024)
Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)
by: Cegielski, Jessica
Published: (2020)
Exploring the role of mitochondria in the changes seen in overall skeletal muscle health associated with ageing and cancer
by: Hatt, Jacob
Published: (2021)
by: Hatt, Jacob
Published: (2021)
The heterogeneity of the functional, metabolic, and molecular responses of skeletal muscle and clinical adaptations to exercise training in pre-clinical and human models
by: Farrash, Wesam
Published: (2020)
by: Farrash, Wesam
Published: (2020)
A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)
by: Crossland, Hannah, et al.
Published: (2017)
The roles of muscle contraction and pharmaceuticals on
restoring glucose uptake in a mouse skeletal muscle
model of immobilization
by: Kirkpatrick, Euan
Published: (2024)
by: Kirkpatrick, Euan
Published: (2024)
Metabolic and functional characterisation of adult skeletal muscle in down syndrome mouse model (Ts1CJe) for insights into hypotonia in human condition
by: Lim, Chai Ling
Published: (2017)
by: Lim, Chai Ling
Published: (2017)
A single 30 min treadmill exercise session is suitable for 'proof-of-concept studies' in adult mdx mice: A comparison of the early consequences of two different treadmill protocols.
by: Crabb, Hannah, et al.
Published: (2012)
by: Crabb, Hannah, et al.
Published: (2012)
The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells
by: Crossland, Hannah, et al.
Published: (2018)
by: Crossland, Hannah, et al.
Published: (2018)
The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
by: Wilkinson, Daniel J., et al.
Published: (2018)
by: Wilkinson, Daniel J., et al.
Published: (2018)
Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression
by: Gakhar, H., et al.
Published: (2015)
by: Gakhar, H., et al.
Published: (2015)
Acute disuse muscle atrophy in health and disease: an investigation of the timecourse, functional effects and a potential treatment strategy
by: Hardy, Edward John Oliver
Published: (2023)
by: Hardy, Edward John Oliver
Published: (2023)
Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men
by: Tsintzas, Kostas, et al.
Published: (2017)
by: Tsintzas, Kostas, et al.
Published: (2017)
The effect of vitamin D on the development and function of skeletal muscle
by: Alliband, Kathryn
Published: (2024)
by: Alliband, Kathryn
Published: (2024)
The role of skeletal muscle in the initiation and progression of knee osteoarthritis
by: Tonge, Daniel Paul
Published: (2010)
by: Tonge, Daniel Paul
Published: (2010)
Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications
by: Jones, K.I., et al.
Published: (2015)
by: Jones, K.I., et al.
Published: (2015)
Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review
by: Rudrappa, Supreeth S., et al.
Published: (2016)
by: Rudrappa, Supreeth S., et al.
Published: (2016)
Insulin resistance in health and disease: exploring the role of disuse skeletal muscle atrophy, testosterone and Beta-Hydroxy-Beta-Methylbutyrate (HMB) in young and older men
by: Shanthaveerappa Rudrappa, Supreeth
Published: (2021)
by: Shanthaveerappa Rudrappa, Supreeth
Published: (2021)
Effects of ageing and vitamin D deficiency on vitamin D receptor (VDR) expression in human skeletal muscle
by: Ong, Terence
Published: (2015)
by: Ong, Terence
Published: (2015)
N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis
by: Terrill, J., et al.
Published: (2012)
by: Terrill, J., et al.
Published: (2012)
The role of bioactive lipids and lipid binding proteins in skeletal muscle
by: Mohd Noor, Mohd Fadly
Published: (2019)
by: Mohd Noor, Mohd Fadly
Published: (2019)
Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
by: Wilkinson, Daniel J., et al.
Published: (2017)
by: Wilkinson, Daniel J., et al.
Published: (2017)
The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
by: Mitchell, W. Kyle, et al.
Published: (2015)
by: Mitchell, W. Kyle, et al.
Published: (2015)
Endocrine and immune responses to resistance training in prostate cancer patients
by: Galvao, D, et al.
Published: (2008)
by: Galvao, D, et al.
Published: (2008)
The role of the vitamin D axis in skeletal muscle physiology: a multi-modal approach
by: Bollen, Shelby
Published: (2024)
by: Bollen, Shelby
Published: (2024)
Investigation of molecular mechanisms regulating palmitate-induced metabolic inflexibility in a cell-based skeletal muscle model: physiological and pharmacological interventions.
by: Chien, Hung-Che
Published: (2020)
by: Chien, Hung-Che
Published: (2020)
Protein nutrition in paediatric Crohn’s disease
by: Aljilani, Bayan
Published: (2025)
by: Aljilani, Bayan
Published: (2025)
Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies
by: Terrill, J., et al.
Published: (2013)
by: Terrill, J., et al.
Published: (2013)
The role of the pyruvate dehydrogenase complex in the regulation of human skeletal muscle fuel metabolism
by: Laithwaite, David
Published: (2009)
by: Laithwaite, David
Published: (2009)
The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles
by: Redshaw, Zoe, et al.
Published: (2014)
by: Redshaw, Zoe, et al.
Published: (2014)
Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.
by: Krause, M., et al.
Published: (2012)
by: Krause, M., et al.
Published: (2012)
Pain behaviour, locomotor activity, inflammation and muscle metabolic dysregulation in pre-clinical animal models of OA and RA and the impact of PPARɣ agonism intervention
by: Casanova, Nuria
Published: (2019)
by: Casanova, Nuria
Published: (2019)
A randomised controlled trial of twelve months protein supplementation on muscle mass and strength in elderly women
by: Meng, Xingqiong (Rosie)
Published: (2010)
by: Meng, Xingqiong (Rosie)
Published: (2010)
Exploration of central and peripheral neural properties in young and old humans
by: Guo, Yuxiao
Published: (2024)
by: Guo, Yuxiao
Published: (2024)
The impacts of bed rest and acute trauma on muscle metabolic health in humans
by: Shur, Natalie F.
Published: (2024)
by: Shur, Natalie F.
Published: (2024)
Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented
by: Krishnan, V., et al.
Published: (2017)
by: Krishnan, V., et al.
Published: (2017)
Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C57Bl/6J mice
by: Soffe, Z., et al.
Published: (2016)
by: Soffe, Z., et al.
Published: (2016)
Similar Items
-
Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice
by: McMahon, C., et al.
Published: (2014) -
Investigating a novel exercise training strategy on neuromuscular health
by: Ely, Isabel A
Published: (2020) -
Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function
by: Smart, Thomas
Published: (2024) -
The impact of leucine-enriched whey protein on skeletal muscle anabolism
by: Ely, Isabel
Published: (2024) -
Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)