A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates inthe preparation of adenosine receptor antagonists, is developed. The method allows introduction of avariety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidi...
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier Science Limted
2009
|
| Online Access: | http://hdl.handle.net/20.500.11937/35003 |
| _version_ | 1848754377816276992 |
|---|---|
| author | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. |
| author_facet | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. |
| author_sort | Dolzhenko, Anton |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates inthe preparation of adenosine receptor antagonists, is developed. The method allows introduction of avariety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine systemvia cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompaniedwith oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structuresof the products are confirmed using NMR spectroscopy and X-ray crystallography. |
| first_indexed | 2025-11-14T08:39:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-35003 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:39:27Z |
| publishDate | 2009 |
| publisher | Elsevier Science Limted |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-350032017-09-13T16:07:33Z A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates inthe preparation of adenosine receptor antagonists, is developed. The method allows introduction of avariety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine systemvia cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompaniedwith oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structuresof the products are confirmed using NMR spectroscopy and X-ray crystallography. 2009 Journal Article http://hdl.handle.net/20.500.11937/35003 10.1016/j.tetlet.2009.07.113 Elsevier Science Limted restricted |
| spellingShingle | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title_full | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title_fullStr | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title_full_unstemmed | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title_short | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| title_sort | new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines |
| url | http://hdl.handle.net/20.500.11937/35003 |