Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents
Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exp...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/34999 |
| _version_ | 1848754376660746240 |
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| author | Peters, S. Glass, D. Greenop, K. Armstrong, B. Kirby, M. Milne, Elizabeth Fritschi, Lin |
| author_facet | Peters, S. Glass, D. Greenop, K. Armstrong, B. Kirby, M. Milne, Elizabeth Fritschi, Lin |
| author_sort | Peters, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study.Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child’s age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.Results: An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.Conclusions: Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT. |
| first_indexed | 2025-11-14T08:39:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-34999 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:39:26Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
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| spelling | curtin-20.500.11937-349992017-09-13T15:28:26Z Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents Peters, S. Glass, D. Greenop, K. Armstrong, B. Kirby, M. Milne, Elizabeth Fritschi, Lin aromatic solvents childhood cancer aliphatic solvents benzene chlorinated solvents Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study.Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child’s age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.Results: An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.Conclusions: Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT. 2014 Journal Article http://hdl.handle.net/20.500.11937/34999 10.1038/bjc.2014.358 Nature Publishing Group fulltext |
| spellingShingle | aromatic solvents childhood cancer aliphatic solvents benzene chlorinated solvents Peters, S. Glass, D. Greenop, K. Armstrong, B. Kirby, M. Milne, Elizabeth Fritschi, Lin Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title | Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title_full | Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title_fullStr | Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title_full_unstemmed | Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title_short | Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents |
| title_sort | childhood brain tumours: associations with parental occupational exposure to solvents |
| topic | aromatic solvents childhood cancer aliphatic solvents benzene chlorinated solvents |
| url | http://hdl.handle.net/20.500.11937/34999 |