Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which cont...

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Bibliographic Details
Main Authors: Mor, I., Carlessi, Rodrigo, Ast, T., Feinstein, E., Kimchi, A.
Format: Journal Article
Published: 2012
Online Access:http://hdl.handle.net/20.500.11937/34852

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